Protease responsive nanosensors were obtained by the attachment of unique green fluorescent bifunctional 3-arylcoumarin-derived fluorogenic substrates to poly(acrylamide-co-N-(3-aminopropyl)methacrylamide) nanoparticles, in which proteolysis results in substantial signal amplification.

Dynamic co-operativity in monomeric enzymes is characterized in terms of a non-Michaelis-Menten kinetic behaviour. The latter is believed to be associated with mechanisms that include multiple reaction pathways due to enzymatic conformational fluctuations. Recent advances in single-molecule fluorescence spectroscopy have provided new fundamental insights on the possible mechanisms underlying re...

A 'co-templating' strategy supported by molecular modelling has been used to prepare, for the first time, silicoaluminophosphates with the SAV and KFI framework topologies, each of which has a three-dimensionally connected pore system with high specific volume.

Firms faced with the decision of whether to standardize or not prior to introducing a new network technology face a tradeoff: Compatibility improves the technology’s chances of consumer acceptance, but it also means having to share the resulting profits with other sponsors of the standard. In this paper, we show that even prior to market introduction of a new technology, the timing of decisions...

We have investigated the magnetic reversal behavior of [(Co/Pt)4Co/CoO]N multilayers that are exchange biased perpendicular to the film plane. We find clear differences in the nucleation properties of the reverse domains of the ascending and descending branches of the hysteresis loops. However, the evolution of the reverse domains, once nucleated, are symmetric to positive and negative field sw...

Within the health policy field, a growing literature is attempting to understand the diverse responses of policy makers to research, and to explain why certain research findings make their way into policy while others are effectively ignored. In this paper we apply a policy analysis framework to the development of cotrimoxazole prophylaxis national policy in Malawi. Arguing that Malawi was one ...

We are indeed encouraged to learn of the successful use of trimethoprim and sulfamethoxazole in combination with other antimicrobial agents for treating disseminated melioidosis, as reported by Tanphaichitra and coauthors In our single experience with life-threatening disease limited to the lungs (Chest 74:222-224, 1978), antagonism occurred when trixnethoprim and sulfamethoxazole were used in ...

It is impossible to test accurately bacterial susceptibility to the trimethoprim-sulfamethoxazole combination co-trimoxazole with a single combined susceptibility disk. However, a variety of factors still affect the result even when separate trimethoprim and sulfamethoxazole disks are used. Experiments with separate disks showed that the optimum conditions for testing the susceptibilities of en...

A comparison of tetracycline, chloramphenicol, and trimethoprim/sulphamethoxazole showed that all hasten the eradication of Vibrio cholerae from the stools of patients with cholera.A four-day period of tetracycline or trimethoprim/ sulphamethoxazole was adequate for eradicating V. cholerae from the stools of all patients, but three days, as suggested by the W.H.O. Expert Committee, was not. Fou...