Dry granulation via roller compaction is increasingly being used as method for the production of oral solid dosage forms. Advantages include a simplified process compared to wet and inherently continuous nature process. A common problem dry granulation, however, loss compactibility granules ungranulated powders. Here we show novel approach minimize during granulation. The intra-granular additio...

Many patient groups, such as the elderly, children, mentally retarded, uncooperative or nauseated, have difficulty in swallowing conventional dosage forms, like tablets. Swallowing conventional tablets will be further hindered by conditions such as unavailability of water, allergic reactions and episodes of coughing1. These problems can be solved by developing rapidly disintegrating and dissolv...

The objective of this study was to evaluate and compare the effect of four superdisintegrants such as croscarmellose sodium (Ac-Di-Sol), crospovidone (Kollidon CL and with smaller particle sizes Kollidon CL-F), sodium starch glycolate (Explotab) in combination with β-lactose and microcrystalline cellulose (Avicel PH-102) as base excipients exhibiting properties of directly compressed tablets an...