The use of supplemental oxygen plays a vital role in the care of the critically ill preterm infant, but the unrestricted use of oxygen can lead to unintended harms, such as chronic lung disease and retinopathy of prematurity. An overly restricted use of supplemental oxygen may have adverse effects as well. Ideally, continuous monitoring of tissue and cellular oxygen delivery would allow clinici...

1 am pleased to see that Dr Schachter and Dr Domingo and colleagues confirm OU observation relative to an increase in arterial Po2 occurring three to six months after initiation of oxygen therapy in stable patients with ‘ However, Dr Schachter takes issue with the recommendation that supplemental oxygen not he discontinned when the arterial Po, increases as a result of the beneficial effects of...

OBJECTIVE This randomized, controlled trial was designed to determine the efficacy of inhaled fluticasone propionate on oxygen therapy weaning in a population of preterm infants who were born at <32 weeks of gestation and experienced moderate bronchopulmonary dysplasia (BPD). METHODS Thirty-two infants who were < or =32 weeks of gestation, had moderate BPD that required supplemental oxygen (f...

BACKGROUND The use of supplemental oxygen in the setting of suspected acute myocardial infarction (AMI) is recommended in international treatment guidelines and established in prehospital and hospital clinical routine throughout the world. However, to date there is no conclusive evidence from adequately designed and powered trials supporting this practice. Existing data are conflicting and fail...

Background: It is assumed giving oxygen to patients with acute myocardial infraction may increase the oxygenation of the ischemic tissue; however, the usefulness of oxygen in these patients has become a challenging topic. Thus, the present study aimed to determine the effect of oxygen inhalation on cardiac biomarkers in patients with acute myocardial infarction.    Methods: This randomized cli...

Bleomycin is an anti-neoplastic agent with potential for producing pulmonary toxicity, attributed in part to its freeradical-promoting ability. The central event in the development of toxicity is endothelial damage of the lung vasculature due to bleomycin-induced cytokines and free radicals, ultimately progressing to lung fibrosis. The treatment is discontinuation of bleomycin, initiation of sy...

The physiologic changes that occur in ventilation during sleep contribute to nocturnal oxygen desaturation in those with lung disease. Nocturnal supplemental oxygen is often used as therapy, although convincing data exist only for those who are hypoxemic both during sleep and wake. Ongoing trials may help address whether oxygen should be used in those with only desaturation during sleep. If use...

PURPOSE Transient tachypnea of the newborn (TTN) is a disorder caused by the delayed clearance of fetal alveolar fluid. β-adrenergic agonists such as albuterol (salbutamol) are known to catalyze lung fluid absorption. This study examined whether inhalational salbutamol therapy could improve clinical symptoms in TTN. Additional endpoints included the diagnostic and therapeutic efficacy of salbut...

conclusions transdermal wound oxygen therapy can effectively promote wound healing in patients with pressure ulcers. results after 12 days of wound oxygen therapy, the number of patients with complete wound healing in the experimental group was significantly greater than that of the control group. moreover, the total mean of wound area in the experimental group was significantly lower than that...

We report a case of sarcoidosis presenting with cor pulmonale of a greater severity than would be expected from the degree of hypoxia and pulmonary fibrosis. Right heart catheterization revealed that mean pulmonary artery pressure was markedly increased (42 mm Hg), was not reduced by supplemental oxygen, but was reduced significantly (25 mm Hg) after 16 weeks of therapy with corticosteroids. Im...