Surfaces that exhibit hydrophobic and hydrophilic characteristics are essential when developing Lab-onChip technologies. The availability of a droplet to be maneuvered on a surface develops from hydrophobic surface characteristics, while non-protein fouling characteristics are found in hydrophilic surfaces. By combining these traits, an ideal surface can be produced for biomedical applications....

it has been known for years that microbial surface active agents have a wide range of applications not only in oil spill environment but also in many industries. their properties including: (i) changing surface active phenomena, such as lowering of surface and interfacial tensions, (ii) wetting and penetrating actions, (iii) spreading, (iv) hydrophylicity and hydrophobicity actions, (v) microbi...

losartan potassium is a well known orally active non-peptide angiotensin ii receptor antagonist. losartan potassium and its principle active metabolites block the vasoconstrictor and aldosterone secreting effect of angiotensin ii by selectively blocking the binding of angiotensin ii to at1 receptors. the drug is reported to promote the decrease in ventricular hypertrophy, salt and water excreti...

Mapping surface hydrophobic interactions in proteins is key to understanding molecular recognition, biological functions, and is central to many protein misfolding diseases. Herein, we report synthesis and application of new BODIPY-based hydrophobic sensors (HPsensors) that are stable and highly fluorescent for pH values ranging from 7.0 to 9.0. Surface hydrophobic measurements of proteins (BSA...

To better understand the role of surface chemical heterogeneity in natural nanoscale hydration, we study via molecular dynamics simulation the structure and thermodynamics of water confined between two protein-like surfaces. Each surface is constructed to have interactions with water corresponding to those of the putative hydrophobic surface of a melittin dimer, but is flattened rather than hav...