BACKGROUND The aim of this study was to evaluate the efficacy of daclatasvir plus asunaprevir therapy in patients infected with hepatitis C virus and determine its relevance to resistant variants. METHODS A total of 629 consecutive patients infected with hepatitis C virus genotype 1 were assessed. Daclatasvir (60 mg/day) plus asunaprevir (200 mg/day) was given for 24 weeks. The virological re...

Software reliability prediction plays a very important role in the analysis of software quality and balance of software cost. The data during software lifecycle is used to analyze and predict software reliability. However, predicting the variability of software reliability with time is very difficult. Recently, support vector regression (SVR) has been widely applied to solve nonlinear predictin...

Objectives: The aim of the study was to evaluate sustained virological response (SVR) after treatment and factors that influence SVR among patients treated for chronic hepatitis C (CHC). Materials and methods: The study was conducted in patients with CHC between April 2007 and March 2011, who had achieved SVR following treatment. They were treated with PEG IFN-α and ribavirin. Patients, whose e...

OBJECTIVE To investigate the relationship between tissue elasticity before and after antiviral therapy and shear wave as well as strain elastography. METHODS FibroScan and real-time tissue elastography were performed before and after antiviral therapy for chronic hepatitis C, and treatment efficacy and elastographic findings were comparatively analyzed. Elasticity was evaluated by measuring l...

Support vector machines are a popular machine learning method for many classification tasks in biology and chemistry. In addition, the support vector regression (SVR) variant is widely used for numerical property predictions. In chemoinformatics and pharmaceutical research, SVR has become the probably most popular approach for modeling of non-linear structure-activity relationships (SARs) and p...

aim : the objective of this study was to evaluate the real outcomes of chronic hepatitis c patients, who treated with interferon plus ribavirin (inf-rbv) and peg-interferon plus ribavirin (peg-rbv). background : despite the peg-rbv has become a standard treatment of hepatitis c virus (hcv) around the world; and in iran too, but in developing countries like as iran, inf-rbv is still used among s...

BACKGROUND The goal of chronic hepatitis C treatment is to remove the virus to avoid progression of HCV-related disease. Sustained virologic response (SVR) is the most widely used efficacy endpoint in clinical studies of hepatitis C, and represents the eradication of HCV from the body. The aim of the current review was to examine the long-term clinical, economic and quality of life benefits ass...

Porosity is considered as an important petrophysical parameter in characterizing reservoirs, calculating in-situ oil reserves, and production evaluation. Nowadays, using intelligent techniques has become a popular method for porosity estimation. Support vector machine (SVM) a new intelligent method with a great generalization potential of modeling non-linear relationships has been introduced fo...

A Sustained virologic response is durable in patients with chronic hepatitis C with peginterferon alfa-2a and ribavirin. The current standard therapy for chronic hepatitis C virus (HCV) infection is the combination of pegylated interferon and ribavirin. The ultimate goal of treatment in patients with chronic HCV infection is to completely eradicate HCV in infected hosts, and prevent liver-relat...

BACKGROUND We assessed changes in left ventricular (LV) volume and function and in regional myocardial wall stress in noninfarcted segments after restrictive mitral annuloplasty (RMA) with or without surgical ventricular restoration (SVR). METHODS AND RESULTS Thirty-nine patients with ischemic cardiomyopathy (ejection fraction ≤ 0.35) and severe mitral regurgitation (≥ 3) were studied before ...