Bu araştırmada lise öğrencilerinin çevresel bakış açıları (ekosentrik, antroposentrik) ile düşünme stilleri arasındaki ilişkinin incelenmesi amaçlanmaktadır. Çalışma açılarının ve stillerinin belirlenmesini çeşitli değişkenlere göre incelenmesini de içermektedir. Keşfedici korelasyonel araştırma modeli gerçekleştirilen araştırmanın örneklemini Türkiye’nin batısında bulunan bir şehirde öğrenim g...

14 Transitions into primary generalized epileptic seizures occur abruptly and synchronously across the brain. 15 Their potential triggers remain unknown. We used optogenetics to causally test the hypothesis that 16 rhythmic population bursting of excitatory neurons in a local neocortical region can rapidly trigger 17 absence seizures. Most previous studies have been purely correlational, and it...

PURPOSE Although absence epilepsy is considered to be a prototypic type of generalized epilepsy, it is still under debate whether generalized 3 Hz spike-and-wave discharges (SWDs) might have a cortical focal origin. Here it is investigated whether focal interictal epileptiform discharges (IEDs), which typically occur in the electro- (EEG) and magnetoencephalogram (MEG) in case of focal epilepsy...

Snap25(S187A/S187A) mouse is a knock-in mouse with a single amino acid substitution at a protein kinase C-dependent phosphorylation site of the synaptosomal-associated protein of 25 kDa (SNAP-25), which is a target-soluble NSF attachment protein receptor (t-SNARE) protein essential for neurotransmitter release. Snap25(S187A/S187A) mice exhibit several distinct phenotypes, including reductions i...

Transitions into primary generalized epileptic seizures occur abruptly and synchronously across the brain. Their potential triggers remain unknown. We used optogenetics to causally test the hypothesis that rhythmic population bursting of excitatory neurons in a local neocortical region can rapidly trigger absence seizures. Most previous studies have been purely correlational, and it remains unc...

As a typical generalized epilepsy, absence epilepsy can be easily identified during seizures (AS) based on the electrophysiological hallmark that synchronous 2–4 Hz spike and wave discharges (SWDs) widely observed in clinical electroencephalography (EEG). Inspired by animal experimental studies AS may regulated neural circuits within outside corticothalamic (CT) network, we employed computation...

ObjectiveThe participation of patients with advanced cancer(s) in clinical trials is vital for new drug development. We aimed to investigate patients’ decision-making processes and satisfaction their decision participate (SWD); the study’s purpose was provide results that can help support high-quality research trials. In addition, we explored how shared (SDM) mediates relationship between under...

al., 1996; Huguenard and Prince, 1994a). The hyperpolarization of membrane potentials induced by the activation of GABAB receptors evokes rebound burst discharges in TC neurons (Crunelli and Leresche, 1991; McCormick and Bal, 1994). This characteristic firing patDaesoo Kim,1,4 Inseon Song,1,4 Sehoon Keum,1 Taehoon Lee,1 Myung-Jin Jeong,1 Sung-Sook Kim,1 Maureen W. McEnery,2 and Hee-Sup Shin1,3,...

Objective: Studies on the actions of exogenous agmatine in experimental models have shown its anti-convulsant effects. However, there are no findings regarding influence absence epilepsy. Therefore, we investigated effects occurrence spike-and-wave discharges (SWDs) Wistar Albino Glaxo Rijswijk rats (WAG/Rij) model genetic Material and Method: Three different doses (20, 40 or 80 mg/ kg) salin...