We evaluated an immunochromatographic point-of-care (POC) syphilis test in 712 pregnant women under field conditions in remote communities of the Amazon region (Brazil), and identified risk factors for syphilis. Women were screened by POC test using whole blood obtained by fingerprick, the fluorescent treponemal antibody absorption (FTA-Abs) test as the gold standard and the Venereal Diseases R...

Syphilis diagnoses in the United States have increased substantially over the past decade, and most cases occurred among men who have sex with men (MSM). Nationally, rates of primary and secondary (P&S) syphilis reported among men increased, from 3.0 cases per 100,000 population in 2001 to 8.2 in 2011. In 2011, approximately 72% of P&S syphilis cases occurred among MSM*, among whom new diagnose...

BACKGROUND In China, female sex workers (FSWs) are at high risk of syphilis infection, but are hard to reach for interventions. Point-of-care testing introduces opportunities for expanding syphilis control measures. Modelling is used to estimate the impact of using rapid tests to screen FSWs for syphilis. In other settings, modelling has predicted large rebounds in infectious syphilis following...

The Authors Reply: Wu and Zhou suggest that some portion of the increase in reported syphilis cases in China may be an artifact of a one-time change in the reporting system in 2004 — an important concern. However, a systematic review of Chinese and English peer-reviewed publications about syphilis trends among both high-risk groups and pregnant women in China suggests that syphilis was spreadin...

same period there was also a series of cases of congenital syphilis. Accordingly, in 1919, a home for children with congenital syphilis (a Welander Home) was provided with accommodation for 20 children from infancy to school age. However, the 1930s witnessed a gradual and considerable decline in the number of notified new cases of acquired syphilis. Congenital syphilis became at the same time s...

OBJECTIVE We aim to analyze trend of syphilis and factors associated with recurrent episodes of syphilis among adults and adolescents attended in a STI/AIDS reference centers in Campinas, state of São Paulo, 2004 to 2012. METHODS Medical records, pharmacy data, and notification database were accessed to analyze trends of syphilis and sociodemographic, epidemiological and clinical variables as...

Using 255 serum samples with various reactivities, we evaluated the Syphilis Fast latex agglutination test (Syphilis Fast) against the Treponema pallidum particle agglutination test (TP-PA) for confirming a diagnosis of syphilis. We found 98.8% agreement between the Syphilis Fast and the TP-PA. The Syphilis Fast, however, had a couple of advantages over the TP-PA: the test takes only 8 min to p...

We present the first reported case of papulonodular secondary syphilis in an HIV-positive transgender female. Syphilis is classified into primary, secondary, latent, and tertiary stages, with secondary syphilis having notably diverse cutaneous manifestations. Our patient presented with diverse lesions throughout her body, all pathologically consistent with papulonodular secondary syphilis. Prop...

The incidence of syphilis in the United States has increased markedly over the last decade, particularly among men who have sex with men (MSM). Although uncommon, ocular involvement is a potentially devastating clinical manifestation of syphilis. Human immunodeficiency virus (HIV) infection appears to increase the risk of ocular syphilis. Because of the lack of pathognomonic features for ocular...

BACKGROUND Although congenital syphilis usually occurs as a result of a failure to detect and treat syphilis in pregnant women, failures of the currently recommended regimen to prevent congenital syphilis have been reported. CASE This report describes an infant with congenital syphilis despite maternal treatment with a regimen exceeding current CDC guidelines. CONCLUSION Regardless of the r...