Abstract: Despite several topical and systemic antifungal drugs are used for the treatment of fungal infection, Amphotericin B (AmB) is still one of the most common first-line choices in systemic fungal infection for over seventh decades from discovery. Amphotericin B which is belonged to the polyene group has a wide spectrum in vitro and in vivo antifungal activity. Its mechanism of antifunga...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Kucharczyk A, Bednarek-Papierska L, Barczyk et al. Principles of management severe asthma patients treated with systemic glucocorticosteroids – Experts’ recommendations on dose reduction and discontinuation these drugs. Alergologia Polska - Polish Journal Allergology. 2022. doi:10.5114/pja.2022.116292. APA Kucharc...

Adequatedrug solubility in the gastrointestinal tract is essential for systemic therapyof orally administered medications. To carry out research on ofpoorly soluble drugs vitro, simulated intestinal fluid (SIF) usedin place of human (HIF). However, typical SIF reflects averagecompositions HIF rather than full range compositions previouslyreported. This study examines a new suite media (based va...

Chloroquine (CQ) and Hydroxychloroquine (HCQ) are antimalarial drugs, with anti-inflammatory properties that justify their use in the treatment of systemic lupus erythematosus rheumatic diseases. A pandemic caused by new coronavirus led entire world’s scientific community to look for drugs already available on market, capable exercising beneficial actions fight against disease. Preliminary stud...

Neuro-inflammation is the inflammation of nervous tissue due to oxidative stress, aging and autoimmunity and the major cause of Alzheimer's, Parkinson's and Huntington's disease. Periodontitis, the inflammation of the gums and supporting structures of the teeth, is a chronic peripheral immuno-inflammatory condition, affiliated with gram- negative, anaerobic bacteria that cause low-grade systemi...

Abstract Clinical case We report a of rheumatoid arthritis‐associated peripheral ulcerative keratitis (PUK) successfully treated with tocilizumab. Despite being systemic corticosteroids and several disease‐modifying antirheumatic drugs, evern though received corneal transplantation, the patient was still going to lose her sight. Tocilizumab resulted in good response control illness preventing p...

kikuchi-fujimoto disease or histiocytic necrotizing lymphadenitis is an idiopathic, self-limiting disorder and predominantly affects young women. we report a 35-year-old female who presented with soft to firm cervical lymphadenopathy and neck pain. she had multiple enlarged cervical nodes. examination of other systems was normal. lymph node biopsy was performed, and the histological features, a...

Systemic administration of drugs into the blood circulation is standard treatment for prevention of metastasis. However, systemic delivery cannot maintain sufficiently high concentrations of anticancer drugs in lymph nodes (LN). Here, we show that giving cisplatin (CDDP) using a lymphatic drug delivery system (LDDS) has the potential to treat false-negative metastatic LN. We found that in MXH10...