14. Tamaki H, Taniguchi Y, Kikuchi A, Yamagami T, Soma T, Matsuoka M. Development of adult T-cell leukemia in donor-derived human T-cell leukemia virus type I-infected T cells after allogeneic bone marrow transplantation. Leukemia. 2007;21(7):1594-1596. 15. Kamihira S, Iwanaga M, Doi Y, et al. Heterogeneity in clonal nature in the smoldering subtype of adult T-cell leukemia: continuity from car...

Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a hardly curable disease with high relapse rate. 20 analogs were synthesized based on the structures of two kinds fungi-derived polyenylpyrrole products (rumbrin (1) and auxarconjugatin-B (2)) to suppress growth T-ALL-derived cell line CCRF-CEM tested for growth-inhibiting activity. The octatetraenylpyrrole analog gave an IC50 0.27 μM in c...

Background: Several studies have demonstrated the immunosuppresive effects of mes-enchymal stem cells (MSCs) in allogeneic or mitogenic interactions. Cell-cell contact inhibition and secretion of suppressive soluble factors have been suggested in this re-gard. Objective: To investigate if adipose derived MSCs could inhibit Jurkat lym-phoblastic leukemia T cell proliferation during coculture. Me...

During the last nine years, two important methodologies have been used to characterize the cell surfaces of normal lymphocytes and malignant lymphoblasts. Normal mature T-cells have a receptor for sheep erythrocyte (E+) while mature B-cells bear membrane-bound immunoglobulin molecules (sIg+). These two findings can be used to divide acute lymphoblastic leukemia of childhood into three major gro...