نتایج جستجو برای: t helper 9
تعداد نتایج: 1132627 فیلتر نتایج به سال:
During differentiation in a thymus, T lymphocytes learn to recognize self alloantigens determined by the H-2 major histocompatibility complex. This imposes certain genetic restrictions on lymphocyte interaction during T cell-mediated immune responses (1-3). For example, antigen-specific helper T cells acquire a binding capacity not only for a given foreign antigen but also for Ia alloantigens o...
Here we provide a mechanism for specific, efficient transcription of the TNF gene and, potentially, other genes residing within multigene loci. We identify and characterize highly conserved noncoding elements flanking the TNF gene, which undergo activation-dependent intrachromosomal interactions. These elements, hypersensitive site (HSS)-9 and HSS+3 (9 kb upstream and 3 kb downstream of the TNF...
Molecular Mechanisms Regulating T Helper 1 versus T Follicular Helper Cell Differentiation in Humans
During differentiation in a thymus, T lymphocytes learn to recognize self alloantigens determined by the H-2 major histocompatibility complex. This imposes certain genetic restrictions on lymphocyte interaction during T cell-mediated immune responses (1-3). For example, antigen-specific helper T cells acquire a binding capacity not only for a given foreign antigen but also for Ia alloantigens o...
The normal counterparts of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) have not been accurately identified. We immunohistochemically analyzed 10 PTCL-NOS cases to examine the expression of the master regulators of T-cell differentiation and of surface antigens, including chemokine receptors. All cases were positive for the master regulator of helper T cells (Th-POK) and the m...
BACKGROUND Inhibition of G-protein βγ (Gβγ) signaling was found previously to enhance T cell receptor (TCR)-stimulated increases in interleukin 2 (IL-2) mRNA in CD4(+) T helper cells, suggesting that Gβγ might be a useful drug target for treating autoimmune diseases, as low dose IL-2 therapy can suppress autoimmune responses. Because IL-2 may counteract autoimmunity in part by shifting CD4(+) T...
Efficient loading of MHC class II molecules with a T helper epitope of choice can be achieved through genetic exchange of the MHC class II-associated invariant chain peptide (CLIP) sequence with a sequence encoding the helper peptide. We have now used this method to engineer a cellular vaccine that continuously expresses a tumor-specific helper epitope in a defined costimulatory context. We pro...
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