PURPOSE To investigate the proton relaxation mechanisms and the optimal MR imaging parameters in superparamagnetic iron oxide (SPIO)-enhanced MR imaging of liver injury. METHODS A liver injury model was created in the rat using carbon tetrachloride. The T1 and T2 relaxation effects of SPIO in normal and injured liver were estimated by ex vivo relaxometry. In vivo laser confocal microscopy of ...

We used a surface-based analysis of T2* relaxation rates at 7 T magnetic resonance imaging, which allows sampling quantitative T2* throughout the cortical width, to map in vivo the spatial distribution of intracortical pathology in multiple sclerosis. Ultra-high resolution quantitative T2* maps were obtained in 10 subjects with clinically isolated syndrome/early multiple sclerosis (≤ 3 years di...

  Introduction:During the month of Ramadan, muslims change their lifestyle. The objective of this study is to evaluate the effect of Ramadan fasting on the energy intake and anthropometry of type 2 diabetics. Methods:Epidemiological study by questionnaire were collected before (T0), during (T1) and after (T3) Ramadan 2013. The data were collected during medical consultations in sanitary establ...

The aim of this study was to establish an advanced analytical platform for complex in vivo pathologies. We have developed a software program, QuantitativeT2, for voxel-based real-time quantitative T2 magnetic resonance imaging. We analyzed murine brain tumors to confirm feasibility of our method for neurological conditions. Anesthetized mice (with invasive gliomas, and controls) were imaged on ...

Background: A brain magnetic state (in terms of magnetic susceptibility distribution χ) can be detected by T2*-weighted MRI (T2*MRI) undergoing a cascade of data transformations. The MRI transformations cause distortions (or spatial morphing), which may be undone by solving the inverse imaging or mapping problem. Upon having a dataset acquired from Blood Oxygenation Level-Dependent (BOLD) funct...

background transfusion-induced iron overload leads to many complications in patients with β-thalassemia major. this study aimed to compare the level of iron stored in the liver and heart measured by mri t2 * with ferritin levels in these patients. materials and methods this study was done on 52 patients with β-thalassemia major aged 7 to 29 years. serum ferritin level was checked and heart and ...

Partial sequences of the RNase P RNA gene (rnpB) were obtained from a number of hemoplasmas and other Mycoplasma species. Phylogenetic analysis of these sequences showed that all hemoplasmas were present within a single clade and were most closely related to Mycoplasma fastidiosum, similar to the results found with 16S rRNA gene phylogeny.

A mutant strain deficient in RNase T was isolated and used to study the role of this enzyme in Escherichia coli. Strains lacking as much as 70% of RNase T activity, alone or in combination with the absence of other RNases, display normal growth properties. However, in cca strains, which lack tRNA nucleotidyltransferase, RNase T-deficient derivatives accumulate lower levels of defective tRNA and...