Dystrophin gene transfer using helper-dependent adenoviruses (HDAd), which are deleted of all viral genes, is a promising option to treat muscles in Duchenne muscular dystrophy. We investigated the benefits of this approach by injecting the tibialis anterior (TA) muscle of neonatal and juvenile (4-6-week-old) dystrophin-deficient (mdx) mice with a fully deleted HDAd (HDCBDysM). This vector enco...

For the problem of processing top-N queries, the threshold algorithm (TA) is an important method in many scenarios. The model of top-N queries with TA has three characteristics: (1) the ranking function is monotone, (2) the query point is fixed, and (3) TA scans the sorted index lists unidirectionally. In many database applications, however, there are opportunities for evaluating top-N queries ...

We present an efficient method for inferring facts from a propositional knowledge base, which is not required to be in conjunctive normal form. This logically-incomplete method, called propositional fact propagation, is more powerful and efficient than some forms of boolean constraint propagation. Hence, it can be used for tractable deductive reasoning in many AI applications, including various...

BACKGROUND Gilbert's syndrome is a chronic or recurrent mild unconjugated hyperbilirubinemia caused by decreased activity of UDP glucuronosyltranferase (UGT1A1). The most common cause of Gilbert's syndrome in Caucasians is homozygous variant of the A(TA)7TAA promoter polymorphism. Alleles with five or eight TA repeats have also been described, but they are very rare in Caucasian populations. ...

background: ferroportin (fpn), a regulator of iron homeostasis is a conserved membrane protein that exports iron across the enterocytes, macrophages and hepatocytes into the blood circulation. fpn has also critical influence on survival of microorganisms whose growth is dependent upon iron, thus preparation of fpn is needed to study the role of iron in immunity and pathogenesis of micoorganisms...

Antibodies provide a suitable tool in fundamental research and their high affinity and specificity make them invaluable for diagnostic and therapeutic applications. A promising alternative to conventional antibodies are the heavy chain antibodies (VHH) of Camelidae having short length, high solubility and stability are preferred to other antibody derivatives. In this study, our goal was product...

Brucellosis is a zoonotic disease in human and animals. Brucella melitensis is one of the most pathogenic species of Brucella in goat and sheep. Omp31 is an outer membrane protein of Brucella that acts as an immunogenic protein. Cytokines are glycoproteins with low molecular weight that play the role of an immune adjuvant and regulate immune responses. Interleukin-2 is one of the most important...

We examine the thermal origin of detected “saw-tooth” shaped Hall resistance ([Formula: see text]) signals in spin–orbit torque switching experiment for antiferromagnetic MnN. Compared with results heavy metal/antiferromagnet bilayers (MnN/Ta), qualitatively same also appear samples metal layer alone (either Ta or Pt) without MnN layer. In addition, [Formula: text] signal changes oppositely dev...