Roller compaction is a dry granulation technique used in the pharmaceutical industry, in which a powder formulation is compressed into a ‘ribbon’ compact between two counter rotating rolls. The ribbon is subsequently milled into granules of a desired size range. Whilst simple in principle, successful control of a roller compaction process is often difficult as it is multivariate in design. Furt...

Most of the pharmaceutical processes involved in the manufacturing of so lid dosage forms are connected with powder flow properties, at least for some of the intermediate steps. Powder flow characteristics are commonl y investigated by various measurements, such as handling angles, tap tes ting, shear cell measurements, etc. All these approaches allow the calc ulation of indices characterising ...

OBJECTIVES The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs). METHODS The moisture content of MCC was optimised using the spray water method and analysed using thermog...

Anxiety is feeling of danger in a person who is threatening with something. Nowadays, anxiety is increased in different populations and, thus it is became an important problem in many countries. Melissa officinalis (Melissa) and Valeriana officinalis (Valerian) are two medicinal plants. These two plants are traditionally used as sedative herbal drugs and new studies on their pharmacological act...

The current study was aimed to investigate the potential of solid self-nanoemulsifying drug delivery system (SSNEDDS) composed of Capmul MCM C8 (oil), Cremophor RH40 (surfactant) and transcutol P (co-surfactant) in improving the dissolution and oral bioavailability of Nateglinide (NTG). Liquid self-nanoemulsifying drug delivery systems (L-SNEDDS) were developed by using rational blends of compo...

Today, tablets are still the most desired form of dosage due to the convenient administration, the chemical and physical stability of the drug in a solid state, and the high production rate of a tabletting machine based on the compaction of powders or granules. Because direct compression vehicles are still in the minority, pharmaceutical powders have to be processed in order to obtain a tailore...

southern part of Nigeria and other west African nations. Examinations of the liver, kidney and duodenum of rats fed a diet containing 10% w/w of dry powdered seed of the kola for 6 weeks has been reported as revealing some useful histological alterations in these organs. In some Nigerian houses it is served as a substitute for the true kola nuts (Cola nitida and Cola acuminata). It has a bitter...

Pemanfaatan potensi sumber daya laut saat ini masih berpeluang besar, misalnya pemanfaatan air yang kaya akan bahan mineral mikro sangat berguna bagi kehidupan belum banyak dilakukan. Penggunaan untuk pertanian sudah mulai dikembangkan, baik secara skala riset maupun aplikatif. Disisi lain Indonesia juga memiliki permasalahan menjadi isu sama di negara yaitu pencemaran akibat sampah. Berdasarka...

Introduction. In modern pharmacology, more and widely used molecular complexes (MC) based on donor-acceptor or, weaker, intermolecular interactions, to stabilize dosage forms in the composition of pharmaceutical substances or their targeted delivery. This trend is actively developing, because molecules forming MK, which has a certain spatial structure, are preserved can be released unchanged. T...