the selected parts of four medicinal plants, achillea millefolium, hibiscus rosasinensis, linum usitatissimum and pluchea lanceolata were extracted in absolute methanol to determine their analgesic activity. analgesic activity was assessed on intact mice by tail flick latency via the tail immersion method. the analgesic activities of these plant extracts were compared with acetylsalicylic acid ...

Background/Aims: Vincristine (VCR) is a potent anticancer drug and neurotoxicity is one of its most important doselimiting toxicities. In this study, we investigated the effect of VCR by neurophysiological recordings and the tail flick test. To elucidate the underlying mechanism of action of VCR, expression of both N-methyl-D-aspartate (NMDA) receptor, an index of glutamate excitotoxity and cal...

BACKGROUND The current study investigated whether racemic bupivacaine and its S(-)- and R(+)-enantiomers, levobupivacaine and dextrobupivacaine, differ in somatic and visceral antinociception and neurotoxicity when administered intrathecally in rats. METHODS In experiment 1, rats intrathecally received 15 microl saline or 0.125, 0.25, 0.5, or 1% bupivacaine, levobupivacaine, or dextrobupivaca...

BACKGROUND Osteoarthritis (OA) is an degenerative disease characterized by chronic joint pain. Complementary and alternative treatment such as acupuncture have been utilized to alleviate pain. The objective of this study was to investigate the analgesic mechanisms of electroacupuncture (EA) in the collagenase-induced osteoarthritis (CIOA) rat model. METHODS Four weeks after inducing CIOA by i...

Methylprednisolone (MP) has been widely used as a standard therapeutic agent for the treatment of spinal cord injury (SCI). Because of its controversial useful effects, the combination of MP and other pharmacological agents to enhance neuroprotective effects is desirable. Magnesium sulfate (MgSO4) has been shown to have neuroprotective and antihyperalgesic effects. In the present study, we soug...

Results: TT treatment of diabetic rats reduced pain score only in chronic phase of the formalin test (p<0.05). Meanwhile, SS administration significantly reduced pain score only at chronic phase of the test (p<0.05). Regarding hot tail immersion test, diabetic rats showed a significant reduction in tail flick latency as compared to control ones (p<0.05). Although TT treatment of diabetic rats i...

The roots of Flemingia strobilifera were extracted in absolute methanol to determine their analgesic activity. The analgesic activity was assessed on intact mice by tail flick latency in tail immersion method. Acetylsalicylic acid in the dose of 300 mg/kg is used as standard drug. Plant extracts were given in the doses of 300, 500 and 1000 mg/kg. Control group received 0.9% NaCl (saline) soluti...

Studies have shown that noxious cutaneous stimulation engages physiologically different antinociceptive systems to inhibit a spinal reflex, tail withdrawal from radiant heat. Two experiments are reported that examine the relationship between the inhibition of the tail-flick response and brain-mediated responses to nociception. The induction of a spinally mediated antinociception was accompanied...

a b s t r a c tintroduction: the nucleus cuneiformis (ncf) and ventrolateral periaqueductal gray (vlpag), two adjacent areas, mediate the central pain modulation and project to the nucleus raphe magnus (nrm). methods: this study examined whether the antinociceptive effect of morphine microinjected into the ncf is influenced by inactivation of vlpag and nrm in rats. animals were bilaterally micr...

The selected parts of four medicinal plants, Achillea millefolium, Hibiscus rosasinensis, Linum usitatissimum and Pluchea lanceolata were extracted in absolute methanol to determine their analgesic activity. Analgesic activity was assessed on intact mice by tail flick latency via the tail immersion method. The analgesic activities of these plant extracts were compared with acetylsalicylic a...