The trial designs were generally similar. Arimidex-Nolvadex (ARNO) 95 trial included 979 women who were randomly assigned after 2 years of tamoxifen to either 3 additional years of tamoxifen or 3 years of anastrozole. The Italian Tamoxifen Arimidex (ITA) trial included 448 women who were randomly assigned after 2 – 3 years on tamoxifen to either tamoxifen or anastrozole for 2 – 3 years. In the ...

Donald Berry in his recent editorial (1) regarding the role of CYP2D6 and tamoxifen highlights several controversies that exist in the clinical and biomarker field for women with breast cancer. The International Tamoxifen Pharmacogenomics Consortium (ITPC) was formed with the intent to aggregate, curate, and analyze the data available in published breast cancer studies with the hope of answerin...

In nature, the combination of composition, structure, and shape determines matter's functional performance to a large extent. Inspired by which, two electrospun Janus nanofiber formulations were created using side-by-side electrospinning in this work. Tamoxifen citrate (TAM) was used as model drug ethyl cellulose (EC) polyvinylpyrrolidone K60 (PVP) polymer carrier matrices. The fibers have line...

It has been proved that kindling model of amygdala is sensitive to estradiol because the latter accelerates the overall rate of kindling. However the effect of estrogen on the seizure process has not been investigated. In this study fully kindled male rats were treated with different doses (10, 30, and 50 µg/kg, i.p.) of estradiol benzoate (EB) daily and such kindling parameters as seizure stag...

background: the objective of this prospective randomized study was to make a comparison between the effects of letrozole and tamoxifen (tmx) in ovulation induction in clomiphene (cc)-resistant women with polycystic ovarian syndrome (pcos). methods: the study comprised a total of 60 infertile women (180 cycles) with cc-resistant pcos selected from the clinics affiliated to the department of obst...

HYPOTHESIS Extracolonic manifestations have a major effect on the morbidity and mortality of patients with familial adenomatous polyposis following proctocolectomy. DESIGN Case review study. SETTING Colorectal unit, university-affiliated hospital. PATIENTS Fifty patients (25 males and 25 females) with familial adenomatous polyposis WHO underwent proctocolectomy between January 1988 and Oc...

Sustained release is highly desired for “efficacious, safe and convenient” drug delivery, particularly those anticancer molecules with toxicity. In this study, a modified coaxial electrospraying process was developed to coat hydrophobic lipid, i.e., stearic acid (SA), on composites composed of the tamoxifen citrate (TC) insoluble polymeric matrix ethylcellulose (EC). Compared electrosprayed TC-...

Tamoxifen is the drug of choice in the treatment of breast cancer.   Recent reports show an increased incidence of endometrial carcinoma in patients taking tamoxifen.   In this article, we report a case of malignant mixed mullerian tumor after tamoxifen use.