CONTEXT Both benign prostatic hyperplasia (BPH) and cataract formation are common in older men. The alpha-adrenergic receptor blocker tamsulosin is frequently prescribed to treat BPH, and research suggests this drug may increase the intraoperative difficulty of cataract surgery. No studies have documented whether use of tamsulosin or other alpha-blocker drug therapies affect the risk of serious...

PURPOSE Postoperative urinary retention (POUR) is one of the most common complications after surgical procedures under spinal anaesthesia. Recent studies have shown the beneficial effects of alpha-adrenergic blockers in preventing POUR. The aim of this prospective study was to investigate and compare the prophylactic effects of tamsulosin and alfuzosin on POUR after urologic surgical procedures...

Since intraoperative floppy iris syndrome (IFIS) was first described in 2005, its association with the systemic alpha-1 adrenergic antagonist, tamsulosin (Flomax®, Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, CT), has become well established [1-7]. The clinical manifestations of IFIS complicating cataract surgery are poor preoperative pupil dilation, iris billowing and prolapse, and ...

OBJECTIVE To study the impact of tamsulosin on the rate of spontaneous passage of distal ureteral stones. METHODS A total of 100 patients with stones sized 10 mm or smaller, located in the distal part of the ureter were included. Patients were randomly assigned to 2 equal groups. Group 1 received 0.4 mg tamsulosin once daily and group 2 received placebo. The investigators and the patients wer...

PURPOSE Overactive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The α1-AR antagonists constitute a variety of drugs according to the receptor subtype affinity. This study investigated the efficacy of tamsulosin, naftopidil, and a combinat...

BACKGROUND Postoperative urinary retention (POUR) is common in neurosurgical patients. The use of alpha-blockade therapy, such as tamsulosin, has benefited many patients with a history of obstructive uropathy by decreasing lower urinary tract symptoms such as distension, infections, and stricture formation, as well as the incidence of POUR. For this study, we targeted patients who had undergone...

BACKGROUND A 23% relative risk reduction (RRR) in prostate cancer (PCa) was shown in men receiving dutasteride in the 4-yr Reduction by Dutasteride of Prostate Cancer Events study, in whom biopsies were protocol dependent. OBJECTIVE Our aim was to explore PCa risk reduction in men with benign prostatic hyperplasia (BPH) from the Combination of Avodart and Tamsulosin (CombAT) study, in which b...

Background: We evaluated the efficacy and tolerability of tamsulosin versus terazosin in patients with signs and symptoms of benign prostatic hyperplasia (BPH). Methods: Patients (N = 1,993) were randomized to tamsulosin (0.4 mg/day) or terazosin (5 mg/day, following titration). The primary efficacy endpoint was total American Urological Association Symptom Index (AUA-SI) score after 4 days of ...

Hypothesis / aims of study Overactive bladder (OAB) associated with bladder outlet obstruction (BOO) is common in elderly men. However, its exact etiology remains unclear. Tamsulosin is an α1-adrenoceptor blocker used in the treatment of symptomatic benign prostatic hyperplasia worldwide, and known to be effective for OAB as well as obstructive symptoms. In this study, we investigated the effec...

INTRODUCTION AND OBJECTIVE Indwelling double J ureteral stents are used routinely in the resolution of ureteral obstruction caused by different etiologies. Evaluation of urinary symptoms related to double-J stent, indicate that these affect 73-90% of patients. We conducted a prospective, randomized study, to evaluate the efficacy of tamsulosin, oxybutinin and combination therapy in improving th...