At synapses throughout the mammalian brain, AMPA receptors form complexes with auxiliary proteins, including TARPs. However, how TARPs modulate AMPA receptor gating remains poorly understood. We built structural models of TARP-AMPA receptor complexes for TARPs γ2 and γ8, combining recent structural studies and de novo structure predictions. These models, combined with peptide binding assays, pr...

Neurotransmission in the brain is critically dependent on excitatory synaptic signaling mediated by AMPA-class ionotropic glutamate receptors (AMPARs). AMPARs are known to be associated with Transmembrane AMPA receptor Regulatory Proteins (TARPs). In vertebrates, at least four TARPs appear to have redundant roles as obligate chaperones for AMPARs, thus greatly complicating analysis of TARP part...

Many image coders map the input image to a transform domain, and encode coefficients in that domain. Usually, encoders use previously transmitted samples to help estimate the probabilities for the next sample to be encoded. This backward probability estimation provides a better PDF estimation, without need to send any side information. In this paper we propose a new method of encoding that goes...

STUDY OBJECTIVES Quitline-an antismoking advertising and a telephone helpline service-is an effective public health intervention strategy for tobacco control. The objective of this short report is to model the relation between placement of antismoking advertisements and calls to Quitline on a given day. METHODS/DESIGN Data on daily Quitline antismoking advertisements, television target audien...

We formulated a mathematical model in order to study the joint influence of demographic and genetic processes on metapopulation viability. Moreover, we explored the influence of habitat structure, matrix quality and disturbance on the interplay of these processes. We showed that the conditions that allow metapopulation persistence under the synergistic action of genetic and demographic processe...

This research aims at examining the learning performance of Arabian horses with use Join-up, Parelli’s Seven Games, and Clicker methods in combination separately. In research, thirty-six mares were examined combinations training applied. Before after application each method, directed to pass through a narrow-spaces walk on tarp. While applying methods, stress parameters, behavioral responses, r...

Year-round operation of biorefineries can be possible only if the continuous flow of cellulosic biomass is guaranteed. If corn (Zea mays) stover is the primary cellulosic biomass, it is essential to recognize that this feedstock has a short annual harvest window (≤1–2 months) and therefore cost effective storage techniques that preserve feedstock quality must be identified. This study evaluated...