نتایج جستجو برای: tau hyperphosphorylation

تعداد نتایج: 21929  

Journal: :Journal of Alzheimer's disease : JAD 2011
Cristina Ploia Xanthi Antoniou Alessandra Sclip Valentina Grande Daniele Cardinetti Alessio Colombo Nadia Canu Luisa Benussi Roberta Ghidoni Gianluigi Forloni Tiziana Borsello

Alzheimer's disease (AD) is a major clinical concern, and the search for new molecules to combat disease progression remains important. One of the major hallmarks in AD pathogenesis is the hyperphosphorylation of tau and subsequent formation of neurofibrillary tangles. Several kinases are involved in this process. Amongst them, c-Jun N-terminal kinases (JNKs) are activated in AD brains and are ...

2018
Cai Shi Jia Zeng Zixi Li Qingjie Chen Weijian Hang Liangtao Xia Yue Wu Juan Chen Anbing Shi

Kainic acid (KA) exposure causes neuronal degeneration featured by Alzheimer-like tau hyperphosphorylation and memory deficits. Melatonin (Mel) is known to protect hippocampal neurons against KA-induced damage. However, the underlying mechanisms remain elusive. In the current study, we investigated the protective effect of melatonin on KA-induced tau hyperphosphorylation by focusing on endoplas...

2016
Gang Wang Yue Huang Li-Ling Wang Yong-Fang Zhang Jing Xu Yi Zhou Guinevere F. Lourenco Bei Zhang Ying Wang Ru-Jing Ren Glenda M. Halliday Sheng-Di Chen

MicroRNA-146a is upregulated in the brains of patients with Alzheimer's disease (AD). Here, we show that the rho-associated, coiled-coil containing protein kinase 1 (ROCK1) is a target of microRNA-146a in neural cells. Knockdown of ROCK1 mimicked the effects of microRNA-146a overexpression and induced abnormal tau phosphorylation, which was associated with inhibition of phosphorylation of the p...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Jenna C Carroll Michiyo Iba Debra A Bangasser Rita J Valentino Michael J James Kurt R Brunden Virginia M-Y Lee John Q Trojanowski

Because overactivation of the hypothalamic-pituitary-adrenal (HPA) axis occurs in Alzheimer's disease (AD), dysregulation of stress neuromediators may play a mechanistic role in the pathophysiology of AD. However, the effects of stress on tau phosphorylation are poorly understood, and the relationship between corticosterone and corticotropin-releasing factor (CRF) on both β-amyloid (Aβ) and tau...

Journal: :The Journal of biological chemistry 2014
Daniel Paris Ghania Ait-Ghezala Corbin Bachmeier Gary Laco David Beaulieu-Abdelahad Yong Lin Chao Jin Fiona Crawford Michael Mullan

We have previously shown that the L-type calcium channel (LCC) antagonist nilvadipine reduces brain amyloid-β (Aβ) accumulation by affecting both Aβ production and Aβ clearance across the blood-brain barrier (BBB). Nilvadipine consists of a mixture of two enantiomers, (+)-nilvadipine and (-)-nilvadipine, in equal proportion. (+)-Nilvadipine is the active enantiomer responsible for the inhibitio...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Nimrod Miller Zhihua Feng Brittany M Edens Ben Yang Han Shi Christie C Sze Benjamin Taige Hong Susan C Su Jorge A Cantu Jacek Topczewski Thomas O Crawford Chien-Ping Ko Charlotte J Sumner Long Ma Yong-Chao Ma

Mechanisms underlying motor neuron degeneration in spinal muscular atrophy (SMA), the leading inherited cause of infant mortality, remain largely unknown. Many studies have established the importance of hyperphosphorylation of the microtubule-associated protein tau in various neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. However, tau phosphorylation in SMA pathoge...

2016
Xiaping He Zhenhui Li Joshua D. Rizak Shihao Wu Zhengbo Wang Rongqiao He Min Su Dongdong Qin Jingkun Wang Xintian Hu

Recent studies have demonstrated that formaldehyde (FA)-induced neurotoxicity is important in the pathogenesis of Alzheimer's disease (AD). Elevated levels of FA have been associated with memory impairments and the main hallmarks of AD pathology, including β-amyloid plaques, tau protein hyperphosphorylation, and neuronal loss. Resveratrol (Res), as a polyphenol anti-oxidant, has been considered...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Olaf Goldbaum Malte Oppermann Melanie Handschuh Deepa Dabir Bin Zhang Mark S Forman John Q Trojanowski Virginia M-Y Lee Christiane Richter-Landsberg

Tau-positive inclusions in oligodendrocytes are consistent neuropathological features of corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementias with Parkinsonism linked to chromosome 17. Here we show by immunohistochemistry that tau-positive oligodendroglial inclusion bodies also contain the small heat-shock protein (HSP) alphaB-crystallin but not HSP70. To stud...

2018
Alexander Stepanov Tatiana Karelina Nikolai Markevich Oleg Demin Timothy Nicholas

Abnormal tau metabolism followed by formation of tau deposits causes a number of neurodegenerative diseases called tauopathies including Alzheimer's disease. Hyperphosphorylation of tau protein precedes tau aggregation and is a topic of interest for the development of pharmacological interventions to prevent pathology progression at early stages. The development of a mathematical model of multi...

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