Traumatic brain injury (TBI) has become a signature wound of the wars in Iraq and Afghanistan. Many American soldiers, even those undiagnosed but likely suffering from mild TBI, display Alzheimer's disease (AD)-like cognitive impairments, suggesting a pathological overlap between TBI and AD. This study examined the cognitive and neurohistological effects of TBI in presymptomatic APP/PS1 AD-tran...

BACKGROUND Violence and traumatic brain injury (TBI) are two major public health concerns. This violence-related TBI, however, has not been studied in Canada and there is little literature on a profile of risk factors and injury severity regarding TBI because of self-inflicted/suicidal and assault/homicidal injury compared with unintentional TBI. METHODS Cross-sectional study using the compre...

OBJECTIVES To estimate sample sizes available for clinical trials of severe traumatic brain injury (TBI) in children, we described the patient demographics and hospital characteristics associated with children hospitalized with severe TBI in the United States. METHODS We analyzed the 2006 Kids' Inpatient Database. Severe TBI hospitalizations were defined as children discharged with TBI who re...

BACKGROUND: Anxiety is a common neuropsychological sequela following traumatic brain injury (TBI). Cognitive Behaviour Therapy (CBT) recommended, first-line intervention for anxiety disorders in the non-TBI clinical population, however its effectiveness after TBI remains unclear and findings are inconsistent. OBJECTIVE: There no current meta-analyses exploring efficacy of CBT as an symptoms TBI...

Introduction Traumatic brain injury (TBI) is amongst the leading causes of morbidity and mortality worldwide. The unprecedented emergence COVID-19 has mandated neurosurgeons to limit viral spread spare hospital resources whilst trying adapt management plans for TBI. We aimed characterize how this affects decision-making on TBI drive strategies cope with future expected waves.Methods Retrospecti...

BackgroundWhilst there has been progress in supportive treatment for traumatic brain injury (TBI), specific neuroprotective interventions are lacking. Models of ischaemic heart and show the therapeutic potential argon gas, but it is still not known whether inhaled (iAr) protective TBI. We tested effects acute administration iAr on oedema, tissue micro-environmental changes, neurological functio...

To investigate the changes of circulating endothelial progenitor cells (EPCs) and stromal cell-derived factor-1α (SDF-1α)/CXCR4 expression in patients with mild traumatic brain injury (TBI) and the correlation between EPC level and the prognosis of mild TBI. 72 TBI patients (57 mild TBI, 15 moderate TBI patients) and 25 healthy subjects (control) were included. The number of circulating EPCs, C...

traumatic brain injury (tbi) is one of the leading causes of death in men under the age of 35 that mostly occurs due to the road accidents. current clinical treatments have not enough repair and prevention of secondary damage caused by cytotoxicity. progesterone, as a primary sex hormone, acts as neuroprotection in tbi and stroke. progesterone increases anti-oxidants and decreases inflammation ...

SUMMARY Traumatic brain injury (TBI) is a major cause of morbidity and mortality. Concussion, a form of mild TBI, might be associated with long-term neurological symptoms. The effects of TBI and concussion are not restricted to cognition and balance. TBI can also affect multiple aspects of vision; mild TBI frequently leads to disruptions in visual functioning, while moderate or severe TBI often...