نتایج جستجو برای: tbx3
تعداد نتایج: 280 فیلتر نتایج به سال:
چکیده زمینه و هدف: بیان ژنهای خودبازسازی Tbx3، Tcl1، Esrrb، Dppa4 در ردههای سلولی سرطانی کولون ( Caco2وHT-29)، کبد (HepG2)، پروستات (LN-Cap)، مثانه HT-1376) ( و در نمونههای تومور انسانی کولون، مثانه و پروستات مورد بررسی قرار گرفت. روش بررسی: سلولهای Caco2، HT-29، HT 1376، Ln Capو HepG2در فلاسکهای T25 کشت داده شدند. همچنین نمونههای تومور انسانی تحت نظارت مستقیم پزشک متخصص و با توجه به عل...
The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype. We used a novel AV nodal myocardium-specific reporter mouse to gain insight into the gene programs determining the formation and phenotype of the developing AV node. In this reporter, green fluorescent pro...
Body size, one of the most important quantitative traits under evolutionary scrutiny, varies considerably among species and among populations within species. Revealing the genetic basis underlying this variation is very important, particularly in humans where there is a close relationship with diseases and in domestic animals as the selective patterns are associated with improvements in product...
The role of Hox genes in the formation of cutaneous accessory organs such as hair follicles and mammary glands has proved elusive, a likely consequence of overlapping function and expression among various homeobox factors. Lineage and immunohistochemical analysis of Hoxc8 in mice revealed that this midthoracic Hox gene has transient but strong regional expression in ventrolateral surface ectode...
Canonical Wnt/β-Catenin Regulation of Liver Receptor Homolog-1 Mediates Pluripotency Gene Expression
Delineating the signaling pathways that underlie ESC pluripotency is paramount for development of ESC applications in both the research and clinical settings. In culture pluripotency is maintained by leukemia inhibitory factor (LIF) stimulation of two separate signaling axes: Stat3/Klf4/Sox2 and PI3K/Tbx3/Nanog, which converge in the regulation of Oct4 expression. However, LIF signaling is not ...
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