psychiatric disorders are very prevalent in epilepsy, 30 to 50 percent of epileptic patients suffer from psychiatric problems. on the other hand, many psychiatric disorders such as dissociative disorder, sleep disorder, impulse control disorder and cyclic disorders have clinical features like epilepsy. therefore, differential dagnosis is very important in dealing with epilepsy. epilepsy has man...

Surgery of temporal lobe epilepsy is the best opportunity for seizure freedom in medically intractable patients. The surgical approach has evolved to recognize the paramount importance of the mesial temporal structures in the majority of patients with temporal lobe epilepsy who have a seizure origin in the mesial temporal structures. For those individuals with medically intractable mesial tempo...

Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to explain the sustained hyperexcitability of chronic epilepsy. Here, through methylation analysis of all annotated C-phosphate-G islands and promoter regions in the human genome, we report a pilot study of the methylation profile...

BACKGROUND Proton magnetic resonance spectroscopy (MRS) of the hippocampus is useful in lateralising the epileptic focus in temporal lobe epilepsy for subsequent surgical resection. Previous studies have reported abnormal contralateral MRS values in up to 50% of the patients. OBJECTIVE To identify the contributing factors to contralateral damage, as determined by MRS, and its extension in pat...

Patients with temporal lobe epilepsy account for about 30 to 40% of the pharmacoresistant epilepsy and can be associated with impairments in multiple cognitive domains, including memory, language, executive function, intelligence and motor speed. Research studies investigating the generalized nature of cognitive impairment in temporal lobe epilepsy, which accounts for the commonest form of foca...

Anterior temporal lobe resection controls seizures in 50-60% of patients with intractable temporal lobe epilepsy but may impair memory function, typically verbal memory following left, and visual memory following right anterior temporal lobe resection. Functional reorganization can occur within the ipsilateral and contralateral hemispheres. We investigated the reorganization of memory function ...

Anterior temporal lobe resection controls seizures in 50–60% of patients with intractable temporal lobe epilepsy but may impair memory function, typically verbal memory following left, and visual memory following right anterior temporal lobe resection. Functional reorganization can occur within the ipsilateral and contralateral hemispheres. We investigated the reorganization of memory function ...