I was conceived in a little log cabin on the shores of Lake Kejimakujik, which may be why I love the lakes and woods of Nova Scotia so much. My mother neither drank nor smoked (then) and the pregnancy was uneventful, except that my parents moved to Norwich, Connecticut, where in 1920 I was born and lived for 9 months. My zygodactylous toes were hidden at first from my mother, for fear she would...

Cyclosporine A (CsA), introduced in the early 1980s, soon became the mainstay of immunosuppression in transplantation. When first introduced, concern was raised about the safety of its use in pregnancy (1). These early reports in fact suggested that cyclosporine might be associated with an increased incidence of intrauterine growth retardation, and clinicians at that time were faced with the de...

DEPARTMENT OF PESTICIDE REGULATION MEDICAL TOXICOLOGY BRANCH SUMMARY OF TOXICOLOGY DATA Trifloxystrobin Chemical Code # 5321, Tolerance # 52415 SB 950 # NA Original: 5/17/00 Revised: 6/26/01 I. DATA GAP STATUS Chronic toxicity, rat: No data gap, no adverse effect Chronic toxicity, dog: No data gap, no adverse effect Oncogenicity, rat: No data gap, no adverse effect Oncogenicity, mouse: No data ...

The article "Experimental Studies on Congenital Malformations" was published in the Journal of Chronic Diseases in 1959. The author, James G. Wilson, studied embryos and birth defects [3] at the University of Florida Medical School in Gainesville, Florida. In his article, Wilson reviewed experiments on birds [4] and mammals from the previous forty years to provide general principles and guideli...

DEPARTMENT OF PESTICIDE REGULATION MEDICAL TOXICOLOGY BRANCH SUMMARY OF TOXICOLOGY DATA Fipronil Chemical Code # 3995, Tolerance # 52062 SB 950 # NA Original: April 26, 2005 Revised: December 12, 2006, July 16, 2010, 12/20/10, 3/25/11 I. DATA GAP STATUS Chronic toxicity, rat: No data gap, possible adverse effect indicated Chronic toxicity, dog: No data gap, possible adverse effect indicated Onc...

An inhalation teratology study was conducted in rats at 10, 50 and 250 ppm ethylene glycol monoethyl ether (EGEE) and in rabbits at 10, 50 and 175 ppm EGEE. This study was designed to supplement a study conducted for NIOSH which showed teratogenic effects in rats at 200 ppm EGEE and in rabbits at about 160 ppm EE. In this study, EGEE was found not to cause teratogenic effects at concentrations ...

Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, Wales, United Kingdom and Department of Anatomy, St. George’s University, St George, Grenada, First Faculty of Medicine, Institute of Histology and Embryology, Charles University Prague, Albertov 4, 128 01 Prague 2, Czech Republic and Second Medical Faculty, Institute of Histology and Embryology, Charles Univers...