The on-surface self-assembly of inorganic atomic clusters and organic molecules offers significant opportunities to design novel hybrid materials with tailored functionalities. By adopting the advantages from both components, have shown great potential in future optoelectrical devices. Herein, we report co-deposition 4,8-diethynylbenzo[1,2-d-4,5-d0]bisoxazole (DEBBA) Se atoms produce a motif-ad...

Protein immobilization plays a key role in the development of all protein-based biosensors in order to achieve good performances. Conventional techniques such as physical adsorption or randomly chemical coupling usually lead to low activity and reproducibility. Therefore there is an essential need for uniformly oriented, covalent immobilization approaches. In this study, the nanobody targeting ...

We present a full account detailing the development of a sequential catalysis strategy for the synthesis of chiral β-alkynyl carbonyl and sulfonyl derivatives. A palladium-catalyzed cross coupling of terminal alkyne donors with acetylenic ester, ketone, and sulfone acceptors generates stereodefined enynes in high yield. These compounds are engaged in an unprecedented, regio- and enantioselectiv...

Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive. By replacing the C-terminal carboxylate of ubiquitin (Ub) with an alkyne functionality, a selective reaction with the active-site cysteine residue of de-ubiquitinating enzymes was observed. The resulting product was shown to be a qua...

Catalytic enantioselective multicomponent processes involving bis(pinacolato)diboron [B2(pin)2], 1,3-enynes, and aldehydes are disclosed; the resulting compounds contain a primary C-B(pin) bond, as well as alkyne- and hydroxyl-substituted tertiary carbon stereogenic centers. A critical feature is the initial enantioselective Cu-B(pin) addition to an alkyne-substituted terminal alkene. This and ...

Photolysis of [M(CO)6] (M /Cr, W) in CH2Cl2 at /78 8C generates [(CO)5M(CH2Cl2)]. Subsequent sequential reaction of [(CO)5M(CH2Cl2)] with terminal alkynes, HC /CR (R /COOMe, Ph, p -Tol), and diazoalkanes, R (R)CN2 (R 1 /Me, Et, Ph; R2 /Me, Et) affords 3H -pyrazole complexes, [(CO)5M / N N C(R) C(H) C /(R)(R)]. These complexes are derived from addition of diazoalkanes to alkyne complex intermedi...