The primary structure ol proteins results from the combination of amino acids in a proper sequence through peptide bonds which tire covalent bonds. Stabilization of ano-helical configuration by hydro­ gen bonding yields a secondary structure. I he spiral is stabilized by hydrogen bonding between the car­ boxyl and the imido groups of the peptide chain which appear in a regular sequence along th...

We report a catalytic enantioselective electrophilic fluorination of alkenes to form tertiary and quaternary C(sp3)-F bonds and generate β-amino- and β-aryl-allylic fluorides. The reaction takes advantage of the ability of chiral phosphate anions to serve as solid-liquid phase transfer catalysts and hydrogen bond with directing groups on the substrate. A variety of heterocyclic, carbocyclic, an...

nitrogen, carbon, alpha-carbon (Ca), oxygen, and hydrogen atoms, and a distinguishing side chain. The backbone of a protein is the linked sequence of these rigid planes. Figure 2 shows several amino acids linked together. The individual amino acids are distinguished from each other by a number of physical chemical properties that give rise to the threedimensional structure [Wilcox, Poliac, and ...

С использованием «квантовой теории атомов в молекулах» (QTAIM) определены интегральные электронные характеристики (заряды и объемы) функциональных групп NH, C(O)H, SH, CH, OH, CHOH, CHCOOH, COOH, CHC(O)NH, CHS, СН, CH(CH)-OH C(O)NH десяти молекул α-аминокислот такого же количества α-аминоальдегидов. Показано, что преобразование структуры (замена СООН на C(O)H) снижает заряд заместителя аминогру...

Chiral metal-templated complexes are attractive catalysts for organic synthetic transformations. Herein, we introduce a novel chiral cobalt(III)-templated complex based on trans-3,4-diamino-1-benzylpyrrolidine and 3,5-di-tert-butyl-salicylaldehyde which features both hydrogen bond donor Brønsted base functionalities. The obtained were fully characterized by 1H, 13C NMR, IR-, UV-vis, CD-spectros...

ECL of several amines containing different numbers of hydroxyl and amino groups was investigated. N-butyldiethanolamine is found to be more effective than 2-(dibutylamino)ethanol at gold and platinum electrodes, and is the most effective coreactant reported until now. Surprisingly, ECL intensities of monoamines, such as 2-(dibutylamino)ethanol and N-butyldiethanolamine, are much stronger than t...

lysozyme is one of the bioactive components of eggs with well known antibacterial potential, widely used in food industry, medicine and pharmaceutics. in this study, the possibility of quail’s egg lysozyme concentration and activity (modified via amino acids dietary supplementation) was investigated. in accordance with lysozyme amino acids profile, four amino acids of: asparagine, arginine, gly...

K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative spatial imaging and atomistic molecular dynamics simulations to examine molecular details of K-Ras plasma membrane binding. We found that the K-Ras anchor binds selected plasma membrane anionic lipids with defined head groups and l...

A novel approach to hyperbranched polymers is presented in this work. Hyperbranched polyesters with a large amount of terminal hydroxyl groups are prepared by a one-pot synthesis from commercially available AB-type and CD(n)-type monomers (n >/= 2). In this paper, Michael addition of diethanolamine (CD(2)) or N-methyl-d-glucamine (CD(5)) to methyl acrylate (AB) generates dominantly AD(n)-type i...