Introduction: Cyclophosphamide (CP) is used for the treatment of various cancers. In spite of its therapeutic importance, a wide range of adverse effects such as reproductive toxicity has been observed following the administration of this drug in human and experimental animals. In the current study, we have investigated the adverse effects of CP on morphology and histology of testis rats. Metho...

OBJECTIVE To describe a novel technique for localizing small testicular mass during testicular-sparing surgery (TSS). METHODS AND RESULTS A 20-year-old man presented with bilateral testicular masses. Both alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (BHCG) levels were raised. Clinical and imaging studies revealed a 2.7 cm and 0.7 cm mass in the right and left testis, respecti...

CONTEXT According to current guidelines, radical orchidectomy is the standard treatment for testis tumours of malignant and unknown origin. Testis-sparing surgery (TSS) has recently been proposed as an alternative option in selected cases. OBJECTIVE Our aim was to analyse the cumulative evidence for TSS in the treatment of adult malignant tumours of different histology, including notes on ope...

  Since the stress influences the biological processes, in the present study the effect of prenatal immobilization stress on the sexual activity of male rats was studied. Adult male and female Wistar rats (Pasteur Institute, Tehran) were copulated. After observing the vaginal plugs, pregnant rats were divided into control and two experimental groups. All groups were kept under the laboratory co...

Introduction Large cell calcifying Sertoli tumors are exceedingly rare. They most commonly benign, but risks for malignancy include older age, larger size of tumor, and solitary tumors. To the author's knowledge, this is first case reported an incidental large tumor when orchidectomy was performed a separate lesion. Case presentation A 31‐year‐old male presented with painless testicular lump. U...

Objective(s): The aim of the present study was to assess the effects of vitamin C (Vit C) on hemolytic anemia induced by phenylhydrazine (PHZ). Materials and Methods: Twenty-four healthy male mice were divided into four groups, randomly: Control group (0.1 ml/day, normal slaine, IP), PHZ group that received only PHZ 8 mg/100 g/48 hr, IP, PHZ+Vit C group that received PHZ 8 mg/100 g/48 hr, IP an...

Background: Cyclosporine-A(CsA) is an immunosuppressive polypeptide which is produced byTolypocladium inflatum gams and can cause infertility. Satureja hortensis or summer savory is a one year plant from Lamiaceae family which is used as a motive drug, anti-bloat, anti-infection and sexual power enhancer. According to positive effects of S. hortensis and negative effects of CsA we will evaluate...

Background: Formaldehyde (FA, H2CO), a member of the aldehyde family and one of the simplest organic molecules, is a flammable, pungent, irritating and colorless gas. This study aimed to investigate the effect of formaldehyde (FA) vapor on sperm parameters and testicular tissue concern about the duration of analysis and the amount of the formaldehyde vapor concentrations. Materials and Methods:...

Background: This study was conducted to investigate the effect of inducing hypothyroidism by propyl-2-thiouracyl (PTU) on lambs testicular histomorphology and plasma testosterone concentration. Materials and Methods: Eighteen Lori-Bakhtari male lambs were divided to 3 groups (n=6) and each received one of the treatments as Control (C: 0 mg PTU/kg BW), Low (L: 10 mg PTU/kg BW) and High (H: 20 mg...