Chloroplasts isolated from pea seadlings grown on water containing 45Ca2+ were treated with local anesthetic tetracaine. Addition of tetracaine inactivated the electron transport activity of donor side photosystem II. This inhibition was accompanied by 45Ca2+ release from the chloroplast membranes as the whole and destroyed by osmotic shock. No such effect was observed when Tris or hydroxylamin...

Procaine, trimecaine and tetracaine inhibit the active transport of norepinephrine and choline in rat brain synaptosomes with half maximal effects at lCr-6.10~ mol/1. Depolarization with veratrine (0.1 mg/ml) or 50 mmol/'l KC1 resulted in neurotransmitter release. Tetrodotoxin (5.10 7 mol/1) or charged tertiary amines (10~ mol/1) prevented the veratrine effect but not that of KC1. Microviscosit...

The existence of two populations of potential-operated Ca 2+ channels in the ureter smooth muscle have been suggested: (1) inactivating Ca 2+ channels which are responsible for the generation of action potentials and phasic contractions, and (2) non-inactivating Ca 2+ channels opened during sustained depolarization which are responsible for the generation of tonic tension (Kochemasova and Shuba...

BACKGROUND Some children feel pain during wound closures using tissue adhesives. We sought to determine whether a topically applied analgesic solution of lidocaine-epinephrine-tetracaine would decrease pain during tissue adhesive repair. METHODS We conducted a randomized, placebo-controlled, blinded trial involving 221 children between the ages of 3 months and 17 years. Patients were enrolled...

Components of nonlinear capacitance, or charge movement, were localized in the membranes of frog skeletal muscle fibers by studying the effect of 'detubulation' resulting from sudden withdrawal of glycerol from a glycerol-hypertonic solution in which the muscles had been immersed. Linear capacitance was evaluated from the integral of the transient current elicited by imposed voltage clamp steps...

We studied the effects of various beta-adrenoceptor (beta AR) antagonists and local anesthetics (LAs), i.e. substances possessing one basic and one lipophilic domain each, on activation of regulatory heterotrimeric guanine nucleotide-binding proteins (G-proteins). In membranes of differentiated HL-60 cells, propranolol activated high-affinity GTP hydrolysis with a half-maximal effect at 0.19 mM...

Prospective, Double-masked, Randomized Trial Comparing Lidocaine Gel to Tetracaine Drops in Femtosecond Laser–assisted LASIK Despite the use of topical anesthetics, patients report intraand/or postoperative pain and discomfort during LASIK, particularly during fl ap creation and during the fi rst several hours after LASIK.1 Evidence suggests that gel preparations of topical anesthetics may be m...