Quantitative determinations of collagen were carried out on rat livers showing cirrhosis due to p-dimethylaminoazobenzene and carbon tetrachloride. A twofold increase in collagen content occurred in cirrhosis due to p-dimethylaminoazobenzene. The average total hepatic collagen as well as the per cent collagen content were doubled. The collagen content after 1(1/2) months of normal diet had fall...

The thermal decomposition of carbon tetrachloride on clean iron was studied in ultrahigh vacuum using molecular beam strategies, where it is found that carbon tetrachloride thermally decomposes on the surface to deposit iron and carbon with exactly identical kinetics as found at high pressures. No gas-phase products are detected and the activation energy for the reaction (14.2 ± 0.5 kcal/mol) i...

Recent studies indicate the chemopreventive role of resveratrol in many animal models like ischemia, rheumatoid arthritis, human cancer, and diabetes. The present study was designed to investigate the chemopreventive potential of resveratrol in rat hepatic injury model by carbon tetrachloride. Male Wistar rats were treated with carbon tetrachloride (0.4 g/kg body weight) intraperitoneally daily...

Zincovit drop is a combined formulation of multivitamins-minerals, flax seed oil and lysine. This study has focused on the in vivo antioxidant potential of Zincovit drop against carbon tetrachloride induced oxidative stress in rats. Rats divided into six groups containing six rats in each group. Zincovit drop at the dose of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day was investigated in carbon...

The distribution of formic, benzoic and 4-methylbenzoic acids between a 0.1 mol dm(-3) (Na+, H+)ClO4- solution and octanol and carbon tetrachloride was studied at five different temperatures of 10 - 30 degrees C. The thermodynamic parameters for the transfer process of monomeric acid between two phases and for the dimerization of monomeric acid in carbon tetrachloride (deltaH and deltaS) were e...

It has been postulated that hepatotoxicity of carbon tetrachloride is related to its prooxidant effect on lipid peroxidation (1-8). DIANZANI and UGAZIO (8) reported that several antioxidants, i.e., propyl gallate, N, N•L-diphenyl-p-phenyl enediamine, and reduced glutathione, which are administered to rats prior to carbon tetrachloride, inhibit significantly the accumulation of hepatic triglycer...

Liver disease has become a global concern worldwide. In absence of reliable liver protective drugs in modem medicine, a large number of medicinal preparations are recommended for the treatment of liver disorders as they are believed to be harmless based on their natural origin. The aim of the present study was to determine the hepatoprotective activity of Phyllanthus amarus plant extract agains...

The study was designed to investigate the role of hepatic metabolic activity on body burden of HCH residue. Male albino rats were orally administered 0, 5, and 10 mg/kg HCH for 90 days, followed by either sodium phenobarbital or carbon tetrachloride treatment for 0, 15 and 30 days after withdrawal of their respective HCH administration. The liver weight was significantly increased at 30 days af...