OBJECTIVE To evaluate the effects of pentoxifylline on hydrochloric acid-induced lung lesions in rats subjected to mechanical ventilation. METHODS Twenty male, adult Wistar-EPM-1 rats were anesthetized and randomly grouped (n=5 animals per group) as follows: control-MV (mechanical ventilation, MV group); bilateral instillation of HCl (HCl group); bilateral instillation of HCl followed by pent...

Tetracyclines, a broad-spectrum class of antibiotics, were discovered in the late 1940s, and became widely used because of their important advantages: they are inexpensive, safe, demonstrate good oral absorption, and are active against a broad range of bacterial pathogens. Unfortunately, as with most antibiotics, the emergence of microbial resistance to tetracyclines has become a serious proble...

nowadays, uncontrolled and frequent use of antibiotics may cause emergence of microbial resistanceamong pathogenic agents. therefore, the use of new synthetic and natural antimicrobial compounds isinevitable. one source of natural compounds in this respect comes from plants. the purpose of this study was to examine the antibacterial effects of peel extracts from sour and sweet pomegranate. meth...

Abstract Tetracyclines belong to the first broad-spectrum, well-tolerated, and easy-to-administer antibiotics, which are effective against plague, cholera, typhoid, syphilis, Legionnaire’s disease, anthrax. Some can also be used treat malaria, Lyme tuberculosis, Rocky Mountain spotted fever, leprosy. Humans encountered these chemical species involuntarily in ancient times, as evidenced from ana...

the forced degradation study of lidocaine hcl was carried out according to the ich guideline q1a (r2). the degradation conditions were assessed to be hydrolysis, oxidation, photolysis and dry heat during 24 h, 48 h and 72 h and then the samples were investigated by gc-fid method and nuclear magnetic resonance (nmr) spectroscopy. according to these results, the degradation products were not obse...

1. In Expt I, a pelleted grass-meal diet was supplemented with hydrochloric acid, added to the grass pellets before feeding, at five levels from 0 to 628 mmol/kg dry matter (DM). Each diet was offered ad lib. for 21 d to five sheep in a 5 x 5 Latin-square design. 2. Voluntary food intake decreased rectilinearly with increasing HCl supplementation (P less than 0.001), to 42% of the control value...

Two cases of pigmentation of the skeletal system due to tetracycline are reported. It is suggested that tetracycline may be stored in bone due to a tetracycline hydrochloride calcium phosphate complex after prolonged tetracycline administration, and that tetracycline may be the antibiotic of choice in certain cases of osteomyelitis. Dark pigmentation of the teeth may be due to prolonged tetracy...

An electrochemical aptasensor was developed for the detection of tetracycline using ssDNA aptamer that selectively binds to tetracycline as recognition element. The aptamer was highly selective for tetracycline which distinguishes minor structural changes on other tetracycline derivatives. The biotinylated ssDNA aptamer was immobilized on a streptavidin-modified screen-printed gold electrode, a...