BACKGROUND The surgical insult induces an inflammatory response that activates P38 MAP kinases and solid tumours can also release cytokines. Therfore inhibition of these pathways may reduce tumour growth We set out to examine the effects of P38-MAPK inhibition on apoptosis, proliferation, VEGF release and cell cycle effects in-vitro and on primary tumour growth in-vivo. METHODS 4T-1 cells (2 ...

Nicotine is one of the most important substances in cigar and the cigarrete Smoke. Smoking may cause an increase in blood pressure and affecting respiratory functions. In this study the effect of nicotine on isolated aorta and trachea of rat and also it's effect on the bronchial resistance, was investigated. In the in vitro experiments, trachca or aorta was removed and placed in an isolated tis...

In this paper a humanoid robot simulator built with the Multi-Robot-Simulation-Framework (MuRoSimF) is presented. Among the unique features of the this simulator is the scalability in the level of physical detail in both the robot’s motion and sensing systems. It facilitates the development of control software for humanoid robots which is demonstrated for several scenarios from the RoboCup Huma...

introduction: mucinous compounds are a group of neutral glycoprotein which have a prime effect for protection of surface epithelium against digestion. studies showed the changes of these compounds in neoplasia and intestinal metaplasia of the stomach. materials and methods: specimens were taken from 25 surgically resected stomach from gastric lesion and it's periphery and processed as routine i...

Abstract Background The phosphodiesterase-1C (PDE1C) and the adenosine A2A receptor (A2AR) are located in a macromolecular cluster expected to modulate cAMP-dependent regulation of intracellular calcium homeostasis cardiac myocytes. In this contect, atrial fibrillation has been associated with high incidence spontanoeus arrhythmogenic waves caused by excessive A2AR activation. On other hand, in...

By increasing house demand for living, the urban development planning has turned to towers, which provides a platform for the growth of the city, regardless of the traditional Iranian's architecture. Among the vital elements in traditional architecture, there are a variety of open and semi-open spaces such as the central courtyard, pool, veranda, balcony, etc that have been provided the needs f...