A rapid, reversed-phase liquid chromatographic method was developed for the quantitative determination of Atorvastatin calcium, its related substances (12 impurities), and degradation impurities in bulk drugs. The chromatographic separation was achieved on a Zorbax Bonus-RP column by employing a gradient elution with water-acetonitrile-trifluoroacetic acid as the mobile phase in a shorter run t...

Grass pellets are a renewable resource that have energy content similar to that of wood. However, the higher ash and chlorine content affects combustion. Thermal degradation analysis of a fuel is useful in developing effective combustion. Thermogravimetric analysis (TGA) of the thermal degradation of grass pellets under inert (nitrogen) and oxidizing (air) atmospheres was conducted. Non-isother...

A specific, accurate, precise and sensitive validated reversed phase liquid chromatographic method has been developed for the determination of valacyclovir in the presence of its degradation products in bulk drug as well as tablet dosage form. As per ICH guideline Q1A (R2), drug was subjected to all stress conditions such as hydrolysis (acidic, neutral and alkaline), oxidation (3 % H2O2 v/v), p...

Determination of alosetron in the presence of its degradation products was studied and validated by a novel HPLC method. The separation of the drug and its degradation products was achieved with the Jones Chromatography C18 analytical column (150 mm x 4.6 mm; 3 µm) with a stationary phase in isocratic elution mode. The mobile phase used was 0.01 M ammonium acetate, pH-adjusted to 3.5 with glaci...

Polyester (P), cotton (C) and Polyester-Cotton (PC) blended fabrics were treated with 350gpl of phosphorous containing flame retardant (FR) chemical. Oxidative thermal degradation of these fabrics before and after the treatment was studied using Thermogravimerty (TG) Differential Thermal Analysis (DTA). From TG output, quantitative mass loss of samples was calculated at definite temperature int...

This paper gives a first study of the thermal and oxidative ageing ELIUM® resins. Chain ends unzipping was observed to be main degradation mechanism under nitrogen whereas an oxidation with random chain scissions is shown predominate in presence oxygen. A simplified kinetic model proposed fits experimental results for thin films at temperatures ranging from 230 310°C oxygen or nitrogen.

Fluconazole(FLK) is a synthetic triazole derivative antifungal agent that has been shown to be effective against a wide range of systemic and superficial fungal infections. A simple, cost effective, precise, accurate, and stabilityindicating isocratic Ultra Performance Liquid Chromatographic (UPLC) method was developed and validated for the determination of FLK in bulk drug and in its tablets. ...

A simple, sensitive and reproducible reversed phase ultra performance liquid chromatography (RP-UPLC) coupled with a photodiode array detector method was developed for the quantitative determination of metaxalone (META) in pharmaceutical dosage forms. The method is applicable to the quantification of related substances and assay of drug product. Chromatographic separation was achieved on an Acq...

The thermal oxidative degradation of polyethylene glycol (PEG) is known to occur in an oxygen atmosphere at elevated temperatures. In this study, PEG radicals assumed to result from thermal oxidative degradation are successfully applied, in combination with compressed CO(2), to initiate a range of free-radical reactions, such as selective formylation of primary and secondary aliphatic alcohols,...

A stability indicating RP-HPLC method was developed for the simultaneous estimation of the anti hypertensive drugs Hydrochlorothiazide, Amlodipine Besylate and Telemisartan. These drugs were subjected to stress studies under different conditions as per ICH guidelines. The separations were carried out using C18 reverse phase column (Agilent ODS UG 5 column, 250mm x 4.5mm,5μm) employing Acetonitr...