a serum survey was conducted to determine the immune status of children 2 months to 6 years old to polio virus type i, ii and iii related to the history of oral polio vaccination in fashapouye (a rural area in the south of teheran). 566 serum samples were obtained from children in 9 different villages and microneutra lization test was performed on 1;10 dilution of these sera. the study revealed...

The main objective of this study was to purify and characterize an esterase from Shewanella sp F88. The enzyme was purified 41-fold and an overall yield of 21 %, using a two-step procedure, including ammonium sulfate precipitation and Q-sepharore chromatography. Molecular weight of the enzyme was 62.3 kDa according to SDS-PAGE data. The enzyme showed an optimum activity at pH 6.5 and 58 ˚C. Evo...

A hyperthermophilic archaeon Pyrococcus horikoshii was isolated from a hydrothermal vent in the Okinawa trough in the Pacific Ocean. It optimally grows at around 100oC. The hyperthermophiles were expected to be good producers of thermostable enzymes active at around 100 oC. The thermostable enzymes have considIkuo MATSUI Biological Information Research Center e-mail: [email protected] AIST T...

BACKGROUND The human papillomavirus (HPV) vaccines have been widely introduced in immunization programs worldwide, however, it is not accepted in mainland China. We aimed to investigate the awareness and knowledge about HPV vaccines and explore the acceptability of vaccination among the Chinese population. METHODS A meta-analysis was conducted across two English (PubMed, EMBASE) and three Chi...

Ebola virus (EBOV) is one of the most virulent pathogens that causes hemorrhagic fever and displays high mortality rates low prognosis in both humans nonhuman primates. The post-exposure antibody therapies to prevent EBOV infection are considered effective as yet. However, owing poor thermal stability mammalian antibodies, their application tropics has remained limited. Therefore, a thermostabl...

Building on our previous efforts to generate thermostable chimeric fungal cellobiohydrolase I (CBH I, also known as Cel7A) cellulases by structure-guided recombination, we used FoldX and a 'consensus' sequence approach to identify individual mutations present in the five homologous parent CBH I enzymes which further stabilize the chimeras. Using the FoldX force field, we calculated the effect o...

In order to reduce as much as possible the a l l e r g i c reactions after vaccination v i t h 17 D vaccine^ we have since 1953 carried out i n the yellow fever vaccination centre of the Paris Pasteur Institute, a test to ascertain s e n s i t i v i t y to the vaccine In a l l a l l e r g i c persons, i n accordance v i t h the method advocated by our late regretted colleague,' Kouwenaar,'^ of ...

Multiple vaccines were developed and administered to immunize people worldwide against SARS-CoV-2 infection. However, changes in platelet count following the course of vaccination have been reported by many studies, suggesting vaccine-induced thrombocytopenia. In this context, designing an effective targeted subunit vaccine with high specificity efficiency for low counts has become a challenge ...