Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase isoenzymes (COX-1, COX-2) are responsible for the production of prostaglandins that play an important role in inflammation, traditional treatment approaches include administration of non-steroidal anti-inflam...

Many compounds bearing five membered heterocyclic rings in their structure have an extensive spectrum of biological activities. The search for new biologically active thiazole analogues continues to be an area of intensive investigation in medicinal chemistry. The present review describes ongoing research in search for new thiazole compounds that can prove useful for the design of future target...

It has been demonstrated that a large amount of thiamine is excreted in the urine without degradation when the vitamin is subcutaneously injected. On the other hand, a relatively small amount of thiothiamine appears in the urine, when it is given by injection, suggesting the in vivo decomposition of thiothiamine. However, in the case of oral administration, thiamine is largely excreted in the f...

The molecules of the title compound, C(12)H(6)N(2)S(4), lie on centres of symmetry. The thiophene and thiazole rings are almost planar and their planes make a dihedral angle of 1.68 (8) degrees. In the crystal structure, there is a relatively short intermolecular S...S contact distance of 3.5786 (9) A.

Charge transport properties of thiophene, thiazole and thiazolothiazole based oligomers have been studied using electronic structure calculations. The charge transport parameters such as charge transfer integral and site energy are calculated through matrix elements of Kohn-Sham Hamiltonian. The reorganization energy for the presence of excess positive and negative charges and rate of charge tr...

The asymmetric unit of the title compound, [CdCl(2)(C(7)H(10)N(2)O(2)S)(2)], contains two complex molecules with similar configurations. The Cd(II) atoms are each six-coordinated by two thiazole N and two carbonyl O atoms from the 2-(2-amino-1,3-thiazol-4-yl)acetate ligand, and by two Cl(-) anions in a distorted octa-hedral geometry. In the crystal, intra- and inter-molecular N-H⋯Cl hydrogen bo...

As part of our project devoted to the synthesis of heterocycles including thiazole rings, some new 5-arylidene-2-thioxo-3-N-arylthiazolidin-4-ones were synthesized by Knoevenagel condensation. An interesting feature of these compounds is that their chirality is induced by that of their 3-N-(2-alkyloxyaryl)-2-thioxothiazolidin-4-one precursors, which in turn is due to the presence of a C2 axis o...

There are other factors which might be studied in relation to the beneficial effect of excess thiazole in the presence of limiting amounts of thiamin or molecularly equivalent quantities of its intermediates. However, it appears clear that the thiazole effect exists under many variations of the conditions under which Phycomyces might be grown in laboratory practice. This is important in the use...