T HE discovery of thiouracil and its derivatives as potent substances for inhibiting the function of the thyroid gland (Astwood, ~943; Astwood et al., I94 ~ and McGinty and Bywater, I94g) has made it possible to study some of the effects of limiting thyroid functions. A detailed report indicative of the effects of these substances on the thyroid gland is given by Astwood et al. (~943). They rep...

Scientific Books: Three Mathematical Text-books: PROFESSOR C. N. MOORE. Biochemistry and Morphogenesis: PROFESSOR DOUGLAS WHITAKER .154 Special Articles: Thiouracil in the Treatment of Thyrotoxicosis: DR. ROBERT H. WILLIAMS and DR. GROSVENOR W. BISSELL. Effect of Various Chemical Agents Affecting Permeability of the Mucosa on the Formation of Ulcers: DR. R. L. DRIVER, G. S. DOZIER and H. C. DEN...

A review of the available literature to date shows 1914 casest of thyrotoxicosis in which thiouracil was employed. This does not include the use of thiourea or other related compounds nor the use of thiouracil in any condition but thyrotoxicosis. Forty-four cases (1.3 per cent) had resulting agranulocytosis, and of these, i per cent) died because of the agranulocytosis. Ninety-three patients pe...

The incorporation of [2-14C]-2-thiouracil and a series of [125l]-5-iodo-2-thiouracils ([125l]ISUra(s)) into cultured Greene hamster melanoma cells was determined in order to establish their properties as false precursors in the melanin-biosynthetic pathway. The cold trichloroacetic acid-precipitable incorpora tion of [2-14C]-2-thiouracil as well as [125l]ISUra into melanoma cells after a 24to 4...

The literature on alcaptonuria has been well summarized (1--6). Paschkis et al. (7) reported that thiouracil and para-aminobenzoic acid inhibited the in vitro conversion of tyrosine to melanin by tryrosinase, and White (8) found that thiouracil inhibited melanuria. Lerner and associates (9) noted that the tyrosinase of mouse melanoma is a copper protein whose activity can be inhibited by the ad...

Several observations have indicated that the conversion of carotene to vitamin A is impaired by a hypothyroid state (1). However, the results of recent studies on the problem are not in agreement (2-6). Determinations of vitamin A in the tissues have been made in only two of the investigations (5,6). According to Wiese et al. (5), thiouracil does not affect the conversion of carotene to vitamin...

Copper complexes obtained from the reactions between 2-thiouracil and cupric hydroxide in different solvents have been investigated. Mononuclear or polynuclear complexes of Cu(I) have been obtained depending on the reaction conditions. Hydroxo complexes of copper(I) have been obtained at pH around 3.5. 2-Thiouracil acts as monoor bidentate ligand in complexes. [Cu(H2TU)2 OH], [Cu5(H2TU)6 (OH)5]...