Radiation therapy of the CNS, even at low doses, can lead to deficits in neurocognitive functions. Reduction in hippocampal neurogenesis is usually, but not always, associated with cognitive deficits resulting from radiation therapy. Generation of reactive oxygen species is considered the main cause of radiation-induced tissue injuries, and elevated levels of oxidative stress persist long after...

BACKGROUND AND AIMS Verbal learning and memory (VLM) are the most impaired cognitive functions noted in schizophrenia. Though its association with negative symptoms is found consistently, only few have compared this relationship at a drug free/naïve state and on antipsychotic medications. Thus the aim of the study was to compare VLM functions in schizophrenia and normal controls and find its as...

Cognitive processes that require spatial information rely on synaptic plasticity in the dorsal CA1 area (dCA1) of hippocampus. Since function hippocampus is impaired aged individuals, it remains unknown how animals make choices. Here, we used IntelliCage to study behavioral support choices female mice living a group. As proxy training-induced plasticity, analyzed morphology dendritic spines and...

Researchers who study the neuronal basis of cognition face a paradox. If they extract the brain, its cognitive functions cannot be assessed. On the other hand, the brain's microcircuits are difficult to study in the intact animal. In this issue of Neuron, Mitchell et al. make use of a promising approach based on waveform analysis to reveal new details about neuronal interactions during visual a...

We argue that conjunction analysis does not solve the problems with subtraction analyses that it sets out to solve and that it has additional problems of its own. We argue that detailed analyses of the tasks set to identify cognitive functions are required for both conjunction and subtraction analyses to achieve their goals of localizing cognitive operations using functional neuroimaging techni...

ory was relatively intact. On discharge, Mr. A continued to show improvement in his cognitive functions, and 2 months after the onset of NMS, his score on MMSE was 25/30 with persistent deficits in immediate and recent memory. He still had retrograde amnesia about the events surrounding the NMS and also had anterograde amnesia with deficits in learning new verbal information. Again, no deficits...