a simple and mild one-pot three-component reaction for the preparation 1,4-dihydropyridines has been developed from various aldehyde substrates, 1,3-dicarbonyl compounds (dimedone) and ammonium acetate (hantzsch method) in the presence of a catalytic amount of phospho sulfonic acid (psa) as an efficient and heterogeneous solid acid in etoh at room temperature. preparation of psa is straightforw...

this research proposes an efficient and easy procedure for the preparation of amides or nitriles from aldehydes. such materials were prepared via one-pot three component condensation reaction of various aldehydes in the presence of nano-ticl4.sio2 as a catalyst under thermal conditions. all reactions proceeded in high yields and in a moderately short reaction time. meanwhile, oximes were obtain...

While some sequential electrophilic aromatic substitution reactions, known as tandem/domino/cascade reactions, have been reported for the construction of aromatic single skeletons, one of the most interesting and challenging possibilities remains the one-pot build-up of a complex aromatic molecule from multiple starting components, i.e., ultimately multi-component electrophilic aromatic substit...

Efficient bismuthand iron-catalyzed three-component syntheses of α-arylglycines have been developed. These methods provide a general, atom-economic route to various N-protected α-arylglycines starting from readily available amides (or carbamates), glyoxalates, and (hetero)arenes with water as the only by-product. Scope and limitations of bismuthand iron-catalyzed reactions are discussed and com...

A facile and highly efficient protocol was applied successfully to synthesize 4H-pyrimido[2,1,b]benzimiazoles and 4H-pyrimido[2,1,b]benzothiazoles through one-pot three-component cyclocondensation reactions of 2-aminobenzimidazole or 2-aminobenzothiazole with dimedone and aromatic aldehydes in the presence of guanidinium chloride under solvent-free conditions. The reactions us...