HSCT from an unrelated HLA-mismatched donor (MMUD) is one of the alternatives where HLA-matched not found. The aim this study was to compare GvHD prophylaxis with anti-thymocyte globulin (ATG) vs. post-transplant cyclophosphamide (PT-Cy). Thirty-nine adult patients were uniformly treated rabbit ATG-Cy-A-MTX and peripheral blood stem cell (PBSC) 40 PT-Cy-MMF-tacrolimus PBSC. This retrospective r...

Differentiation-dependent thymocyte migration in the thymus may be important for T lymphopoiesis and might be regulated by thymic chemoattractants. We examined modulation of chemotactic responsiveness of thymocyte subsets during their early to late stages of development in response to 2 thymus-expressed chemokines, SDF-1 and CKbeta-11/MIP-3beta/ELC. SDF-1 shows chemotactic preference for immatu...

Thymoglobulin (ATG) is a polyclonal rabbit antibody against human thymocytes used as a T cell-depleting agent to prevent or treat allotransplant rejection. The aim of the present study was to investigate the effect of low dose ATG treatment exclusively on T cells using a humanized BALB/c human CD3Ɛ transgenic mouse model expressing both human and murine T cell receptors (TCR). Mice received a s...

A case of pure red cell aplasia, which did not respond to corticosteroids, splenectomy, or cyclophosphamide, has been described. In vitro studies performed with the patient’s marrow showed a much smalter response to erythropoietin than that observed with previous patients who did respond to cyclophosphamide. The patient’s plasma and -yG-globulin fraction inhibited the rate of heme synthesis of ...

A case of pure red cell aplasia, which did not respond to corticosteroids, splenectomy, or cyclophosphamide, has been described. In vitro studies performed with the patient’s marrow showed a much smalter response to erythropoietin than that observed with previous patients who did respond to cyclophosphamide. The patient’s plasma and -yG-globulin fraction inhibited the rate of heme synthesis of ...

A case of pure red cell aplasia, which did not respond to corticosteroids, splenectomy, or cyclophosphamide, has been described. In vitro studies performed with the patient’s marrow showed a much smalter response to erythropoietin than that observed with previous patients who did respond to cyclophosphamide. The patient’s plasma and -yG-globulin fraction inhibited the rate of heme synthesis of ...