A 68-year-old man was admitted to our hospital to undergo an examination for nephrotic syndrome while concurrently complicated with recurrent thymoma in the parietal pleura and retroperitoneum. He had been diagnosed with invasive thymoma and had undergone thymo-thymectomy seven years previously. Based on the renal biopsy findings, his nephrotic syndrome was ascribed to minimal change disease. H...

Thymoma is a disease with malignant potential, which has a recurrence rate after complete resection ranging from 5 to 50 %. Multiple studies on the risk factors, treatment or prognosis have been reported. Many of them are controversial, however. In this review, we summarized some accepted risk factors, means of diagnosis and different treatments of recurrent thymoma. The risk factors of recurre...

The aim of the present study was to examine the feasibility and efficacy of thoracoscopic radical resection of large retrosternal thymoma using artificial pneumothorax. A retrospective analysis was performed on 19 patients with bulky thymoma who underwent thoracoscopic resection using artificial pneumothorax by CO2 insufflation. The operations were performed with unilateral or bilateral thoraci...

OBJECTIVES To report a case of multifocal cortical encephalitis associated with thymoma and to establish an association of this thymoma-related paraneoplastic syndrome with voltage-gated potassium channel antibodies. DESIGN Case report. SETTING University hospital. PATIENT A 43-year-old woman with a history of seropositive myasthenia gravis and successfully treated invasive thymoma. Four ...

Purpose. We examined the role of miR-20b in development of thymoma-associated myasthenia gravis, especially in T cell proliferation and activation. Materials and Methods. Using qRT-PCR, we assessed expression levels of miR-20b and its target genes in cultured cells and patient samples and examined the proliferation of cultured cells, using MTT cell proliferation assays and flow cytometry based ...

The actual incidence of multiple thymoma is unknown and rarely reported because it remains controversial whether the cases represent a disease of multicentric origin or a disease resulting from intrathymic metastasis. In this case, a patient underwent total thymectomy for multiple thymoma with myasthenia gravis via bilateral video-assisted thoracic surgery. A well-encapsulated multinodular cyst...

Introduction: Thymoma is a rare benign tumor with a largely indolent growth pattern. Anterior mediastinal mass is the commonest clinical presentation. It is to be distinguished from invasive thymoma i.e. thymic carcinoma by the presence of cellular features of malignancy and a greater incidence of local invasion and embolic metastases. Case presentation: We report a case of thymoma in a 25 year...

We report a case of ectopic middle mediastinal thymoma in an asymptomatic 50-year-old woman.Chest X-ray, CT, MRI and FDG-PET/CT examinations were performed preoperatively. The tumor was removed by video-assisted thoracic surgery, and the pathological diagnosis was type B3 thymoma of the World Health Organization classification and stage II thymoma of the Masaoka clinical staging system.Postoper...

BACKGROUND Thymomas are typically benign tumors of thymic epithelium. Metastases to distal sites, particularly intracranial locations, are extremely rare. Herein, we present the third case of thymoma and the second invasive thymoma to metastasize to the cavernous sinus, adjacent to the pituitary. CASE DESCRIPTION A 41-year-old female patient presented with headaches, stuffy nose, and drooping...

BACKGROUND Thymoma is known to cause autoimmune neuromuscular disease. However, anti-glutamate receptor antibody limbic encephalitis (LE) with thymoma is relatively rare. CASE PRESENTATION A 68-year-old woman was admitted with progressive memory impairment and personality change. Brain magnetic resonance imaging (MRI) revealed high intensity in the bilateral limbic areas on T2-weighted fluid-...