Monoclonal antibodies to human thyroglobulin were produced using the hybridoma technique. Two monoclonal antibodies D5I and F9I were radiolabeled with 125I and used for radioimmunolocalization studies in an immunosuppressed animal model bearing xenografts of human thyroid tumor tissue. Biodistribution studies were carried out at various time intervals post-injection. Maximum tumor uptake was ob...

The amplification of thyroglobulin (TG) mRNA in peripheral blood of patients with thyroid cancer has been studied for almost one decade, but its real contribution for diagnosis of cancer relapse has not yet been established. In the present paper we report the case of a patient with papillary thyroid cancer with undetectable stimulated serum thyrogobulin levels after thyroid ablation. Follow-up ...

A 3 year old girl presented with a three week history of lethargy, constipation, and joint swelling. Investigation showed primary hypothyroidism associated with immunological changes including thyroglobulin antibodies. Reassessment several months after beginning thyroxine treatment confirmed persisting hypothyroidism. Primary hypothyroidism may present as a rapid onset disorder.

McGrath, R., Preda, V., Clifton-Bligh, P., Robinson, B., Sywak, M., Delbridge, L., Ward, P., Clifton-Bligh, R., Learoyd, D. (2016). Is there a role for an ultrasensitive thyroglobulin assay in patients with serum antithyroglobulin antibodies? A large (Australian) cohort study in differentiated thyroid cancer. Clinical Endocrinology, 84(2), 271-277. ...

OBJECTIVE In this study we investigate the possible relation of thyroid dysfunction and thyroid antibodies to hyperemesis gravidarum. MATERIAL AND METHODS Thirty-seven patients with hyperemesis gravidarum and 33 healthy controls have been included in this study. RESULTS Thyroid dysfunction was significantly more common than in controls (38% vs 6%, p=0.002). Thyroglobulin antibodies were als...

Antibodies interact with the follicular cell, colloid, or thyroglobulin antigens and activate the complement cascade and cell-mediated cytotoxicity. The progressive destruction of follicles and secondary fibrosis eventually leads to a failure of thyroid hormone production. More than 60 or 70% of the thyroid tissue needs to be destroyed before we see changes in laboratory measures of thyroid fun...

OBJECTIVE To prospectively evaluate the heterogeneous appearance of the thyroid gland, reflecting inflammation and destruction in euthyroid Hashimoto's thyroiditis (HT), we investigated the clinical utilities of the heterogeneity index (HI) [the coefficient of variance (CV) of the ultrasonographic (US) intensities], focusing on anti-thyroid peroxidase antibodies (TPO-Ab), which represent not on...

conclusions thyroid dysfunction was not higher in sle patients compared to healthy individuals. however, anti-tg antibodies were higher in sle patients. it has not yet been established that thyroid function tests should be performed routinely in sle patients. results the mean age of sle patients and controls were 32.16 ± 9.19 and 32.48 ± 9.47 years, respectively (p = 0.821). patients had signif...

Background: Type 1 diabetes mellitus (T1DM) as an autoimmune disorder is associated with other autoimmune diseases such as autoimmune thyroid (AIT) disease. The aim of this study was to determine the prevalence of AIT in children who were referred to Amirkola Endocrine Clinic (north of Iran). Methods: This cross-sectional study was carried out on 100 diabetic children aged 1-15 years during ...