OBJECTIVE: Diabetes mellitus and thyroid disease are the two common endocrinopathies seen in adult population. Studies to evaluate thyroid disorders in patients with type 2 diabetes are lacking. The aim of this study was to compare prevalence of thyroid dysfunction and autoim-munity in type 2 diabetic patients with age and sex matched non-diabetic control group. MATERIAL AND METHODS: Among pat...

Introduction: Thyroglobulin (Tg) measurement is important for detection of disease recurrence in patients with differentiated thyroid carcinoma (DTC). However, its affected by Tg autoantibodies (TgAb). Calculation recovery may complement quantitative TgAb interference. This study aimed to determine the prevalence positivity samples received from post-thyroidectomy DTC Hospital Pulau Pinang (HPP...

Thyroid microsomal antigen was studied using sera from rats immunized with solubilized human thyroid microsomal fraction. The methods used were gel immunodiffusion and the fluorescent antibody technique (FAT). Kidney, liver and thyroid microsomal fractions were solubilized by 0.5% Triton X-100 PBS. Rat sera immunized with solubilized thyroid microsomal fraction had a few precipitin antibodies t...

Antibody-dependent macrophage-mediated cytotoxicity was studied to determine the significance of cytophilic anti-thyroglobulin antibody (ATgA) present in the sera of patients with Hashimoto's thyroiditis. Effector cells were normal human monocytes or guinea-pig peritoneal exudate cells, and target cells were human thyroglobulin(Tg)-coated chicken erythrocytes. Cytotoxicity was evaluated by morp...

Investigations in patients with thyroid disease led to the discovery of serum factors which react like antibodies with thyroglobulin-containing extracts of human thyroid gland (1, 2). These serum factors have been shown to be among the av-globulins (3). Pressman and colleagues (4) reported that the serum anti-thyroglobulin activity in one patient was associated with the y-macroglobulins. Korngo...

Thyroglobulin is the major secretory protein of thyroid epithelial cells. Part of thyroglobulin reaches the circulation of vertebrates by transcytosis across the epithelial wall of thyroid follicles. Clearance of thyroglobulin from the circulation occurs within the liver via internalization of thyroglobulin by macrophages. Here we have analyzed the interaction of thyroglobulin with the cell sur...