Autoimmune thyroiditis is one of the most common causes acquired hypothyroidism in children and adolescents. Both genetic susceptibility environmental factors play a role etiopathogenesis. We report two cases autoimmune here with varied presentation. them had different clinical features at On investigation, both elevated thyroid-stimulating hormone (TSH), low T4 anti-Thyroid peroxidase (TPO) an...

BACKGROUND Neurofibromatosis type 1 is an autosomal dominant neurocutaneous disorder in which the coexistence of autoimmune thyroiditis and thyroid gland tumours has been reported previously. AIMS To determine the thyroid function and autoimmune thyroid diseases in neurofibromatosis type 1 patients in order to identify the possible association between neurofibromatosis type 1 and thyroid dise...

Autoimmune thyroid diseases (AITD) are characterized by the presence of thyroidspecifi c autoantibodies. These are directed against thyroid microsomes, for which the main target antigen is thyroid peroxidase (TPO), against thyroglobulin (TG), or against the thyroid stimulating hormone (TSH) receptor. AITD frequently occur in combination with other autoimmune diseases, such as myasthenia gravis,...

Abstract. A case of a female, 10-year-old rhesus macaque (Macaca mulatta) with spontaneous chronic lymphocytic thyroiditis is presented. At necropsy, the thyroid gland was slightly enlarged, up to 2 mm large, round, confluent, beige foci on surface both lobes. Histopathologic features resembled human Hashimoto's thyroiditis: multifocally, interstitium infiltrated by lymphocytes and variably siz...

A cDNA clone encoding a thyroid-specific enhancer-binding protein (T/EBP) was isolated from a rat thyroid-derived FRTL-5 cell lambda gt 11 expression library, using a double-stranded oligonucleotide probe. This oligonucleotide was previously demonstrated to have the strongest binding affinity among three cis-acting DNA elements within the thyroid-specific enhancer region located 5.5 kbp upstrea...

Hashimotos encephalopathy is an autoimmune disorder, with high titres of antithyroid peroxidase antibody, usually with a clinically and biochemically normal thyroid function. Here we present a case of hashimotos encephalopathy in a 34yr old man, who presented with acute onset of cognitive impairment on a background of psychiatric illness. Initially a probability of neuroleptic malignant syndrom...

We herewith describe a patient with acute confusion, expressive aphasia and generalized seizures. A through workup excluded most causes of encephalopathy. He was, however, found to have TSH=18.6 MIU/ml, T3reverse=0.44nmol/L, T4=0.8ng/dl and Anti-Thyroid-Peroxidase AB titer >1000 IU/ml. Based on the above findings the patient was diagnosed with Hashimoto's encephalopathy and his mental status sh...

Nitrate is a wide spread contaminant of ground and surface water. The source of nitrate in the ground water may be from run off or seepage from fertilized soil, municipal or industrial waste water, land fills, septic system, urban drainage or decaying plants. Human and animal systems are affected severely on nitrate exposure. The study was to investigate the effect of dietary nitrate exposure o...

BACKGROUND Isotretinoin is widely used in the treatment of acne. AIMS We investigated the effects of isotretinoin on thyroid function tests and thyroid volume in acne patients. METHODS In this prospective study, a total of 104 acne patients were included. Sixty-six patients were treated with isotretinoin for at least 4 months. Thirty eight patients were included in the control group. The le...

Background Lichen planus pigmentosus (LPP) is considered a chronic and progressive variant of lichen planus. Although pigmentation occurs in the sun exposed areas, the etiology remains unknown and there are no appropriate treatment guidelines. Association with thyroid disorder has been described in various disorders of pigmentation. Objective The objective of this study was to find the associat...