Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced t...

despite many advances in the field of cancer treatment, intra-cranial tumor cases still have a poor prognosis. this research has been carried out in order to describe age and sex distributions and histopathological characteristics and site of intra-cranial tumors. we studied 425 patients with intra-cranial tumor whose samples were examined in pathology center of imam khomeini hospital from 1991...

症例1:58歳,女 性. 初診:昭 和60年10月14日 主訴:前 頚部腫瘤 現 病歴:4年 前 よ り前頚部に小腫 瘤 を触 れる も自覚 症状 ないため放 置.特 に増大 せず. 既往歴:特 になし 現症:右 前頚部 に直径2cm大 の弾性硬 の腫瘤 を触 れ,嚥 下運動 とともに可動.喉 頭正常. 検査:血 液細胞学的生化学的異常 はな く,赤 沈, CRP,γ-gl分 画,血 清IgG,RA,ト リオ ソル ブ, T3,T4抗 サイ ログ ロブ リン抗体,抗 マイ ク ロゾーム 抗体,カ ルシ トニン,CEAは すべて正常であ った. 頚部X線 撮影 で気管 の偏位,甲 状腺部の異常石灰 化, 頚部食道(造 影)の 偏位,変 形,通 過障害はなか った (写真1a,2a), 123Iシ ンチ グラフィーで甲状腺右葉外側 に径1cmの cold areaを 認め,正 常 甲状腺...

Introduction: Primary squamous cell carcinoma (SCC) of the thyroid gland is one of the rarest types of all reported thyroid malignancies worldwide. It is very aggressive in nature and carries a poor prognosis. The surgical resection with adjuvant radiotherapy and chemotherapy is the most recommended treatment despite its poor reported outcome.  Case Report: A 74-year-old woman presented wit...

main thyroid disorders are hypothyroidism, hyperthyroidism, all kinds of swellings and tumors. generally, thyroid disorders increase the risk of obesity, heart and vessels disease, anxiety, hair dye, sexual disability and infertility clearly. patients with these diseases have to be aware of appropriate actions for short or long land, air and sea travels in order to prevent side effects of thyro...

INTRODUCTION In normal conditions follicle-stimulating hormone receptors (FSHR) are expressed in the ovary and the testis. They can also be expressed in gonadal tumors. However, recently we have found FSHR immunostaining in pituitary adenomas, adrenal tumors and neuroendocrine tumors (carcinoids). The aim of this study was to determine whether the same occurs in thyroid tumors. MATERIAL AND M...

Recently we identified a molecular basis for differentiating benign and malignant follicular thyroid tumors. The purpose of these studies was to determine whether molecular analysis can be used to differentiate papillary thyroid carcinomas from benign thyroid nodules. Gene expression patterns of 14 papillary thyroid carcinomas and 21 benign tumors were analyzed by oligonucleotide array analysis...

DNA microarrays allow quick and complete evaluation of a cell's transcriptional activity. Expression genomics is very powerful in that it can generate expression data for a large number of genes simultaneously across multiple samples. In cancer research, an intriguing application of expression arrays includes assessing the molecular components of the neoplastic process and utilizing the data fo...

Thyroid cancer exhibits a spectrum from relatively indolent tumors to tumors that are invasive, metastatic, or progress to poorly differentiated carcinoma. Microarray expression analysis of thyroid cancer cell lines has implicated a member of the melanoma-associated (MAGE) family of cancer-testis antigens in thyroid cancer development and progression. We performed this study to validate the rol...