As we described elsewhere, tics are defined as “sudden, rapid, recurrent, nonrhythmic, stereotyped motor movements or vocalizations”and have clinical concerns1.Tics are likely to differ in terms of the body location, number, frequency, complexity, intensity or forcefulness, noticeable and resulting social consequences2. Intervals between tics can range from seconds, hours or even days. The forc...

OBJECTIVE To determine whether caffeine ingestion was temporally correlated with tics in 2 healthy children. METHODS Two first-degree cousins were observed over a period of approximately 3 years, and the presence and absence of tics was recorded and correlated with consumption of or abstinence from caffeinated foods or beverages. RESULTS Appearance and disappearance of tics were closely and...

Tumor-initiating cells (TICs) have been shown both experimentally and clinically to be resistant to radiation and chemotherapy, potentially resulting in residual disease that can lead to recurrence. In this study, we demonstrate that TICs isolated from p53 null mouse mammary tumors repair DNA damage following in vivo ionizing radiation more efficiently than the bulk of the tumor cells. Down-reg...

The recognition that the progression of many tumors may be driven by specific subpopulations of cells with stem/progenitor-like properties (tumor-initiating cells or TICs, a.k.a. cancer stem cells) represents an important recent paradigm shift in cancer biology and therapeutics. TICs in solid tissues are expected to interface with the extracellular matrix (ECM), which can strongly influence cel...

BACKGROUND EpCAM or CD133 has been used as the tumor initiating cells (TICs) marker in hepatocellular carcinoma (HCC). We investigated whether cells expressing with both EpCAM and CD133 surface marker were more representative for TICs in hepatocellular carcinoma Huh7 cells. METHODS Four different phenotypes of CD133(+)EpCAM(+), CD133(+)EpCAM(-), CD133(-)EpCAM(+) and CD133(-)EpCAM(-) in Huh7 c...

Tumor-initiating cells (TICs) are defined as a specialized subset of cells with tumor-initiating capacity that can initiate tumor growth, tumor relapse and metastasis. In the present study, osteosarcoma TICs (OS-TICs) were isolated and enriched from the osteosarcoma U2OS and MG-63 cell lines using sphere formation assays and serum-depleted media. These enriched OS-TICs showed the expression of ...

Pancreatic cancer is an aggressive solid tumour characterized by its local invasion, early metastasis and resistance to standard chemotherapy or radiation therapy. Tumour initiating cells (TICs) are not only capable of self-renewal and differentiation, but also play an important role in multi-drug resistance, and thus become a popular topic in cancer research especially in pancreatic cancer. In...

Tics are rapid, repetitive, stereotyped movements or vocalizations that arise from neurobiological dysfunction and are influenced by environmental factors. Although persons with tic disorders often experience aversive social reactions in response to tics, little is known about the behavioral effects of such consequences. Along several dimensions, the present study compared the effects of two tr...

The cortico-basal ganglia pathway is involved in normal motor control and implicated in multiple movement disorders. Brief repetitive muscle contractions known as motor tics are a common symptom in several basal ganglia related motor disorders. We used focal micro-injections of the GABA-A antagonist bicuculline to the sensorimotor putamen of behaving primates to induce stereotyped tics similar ...

Este artigo tem como objetivo analisar trabalhos que tratam sobre a integração das Tecnologias da Informação e Comunicação (TICs) no espaço escolar sua interlocução com o Projeto Político Pedagógico (PPP). A pesquisa trata-se de uma Revisão Sistemática Literatura (RSL) natureza quanti-qualitativa na metodologia. Como resultado, constatou-se ainda existe carência pesquisas relacionem as tecnolog...