BACKGROUND Thyroid hormone treatment in brain-dead organ donors has been extensively studied and applied in the clinical setting. However, its clinical applicability remains controversial due to a varying degree of success and a lack of mechanistic understanding about the therapeutic effects of 3,3',5-Triiodo-L-thyronine (T3). T3 pre-conditioning leads to anti-apoptotic and pro-mitotic effects ...

Background: GABAergic drugs can modulate the rewarding properties of morphine. The objective of this study was to evaluate the effects of isoniazid, as a GABAergic agent, on the rewarding effects of morphine. Methods: Eighteen groups of female mice (eight per group) were used in a conditioned place preference (CPP) study. On the conditioning phase of the CPP p...

Cells implanted after injury may remodel undesirably with improper mechanical stimulation from surrounding tissue. Proper conditioning of tissue engineered constructs before implantation can lead to suitable tissue architectures, along with an extracellular matrix (ECM) environment that more closely mimics native tissue. Additionally, cell implantation without bulky polymeric scaffolding is oft...

The total number of words in the manuscript, including entire text from title page up to figure legends: 7085 The number of words of the abstract: 200 Abstract The subject of presented paper is effective recognition of radiating spicules on digital mammograms. The presence of the spicules is a dominant symptom of neoplastic breast lesionscalled architectural distortions. The originality of the ...

Keratinocyte growth factor (KGF) is important in tissue repair and wound healing and its administration can abrogate chemical- and radiation-induced tissue damage in rodents. We investigated KGF as a therapeutic agent for the prevention of graft-versus-host disease (GVHD)-induced tissue damage, morbidity, and mortality in an established murine allogeneic bone marrow transplantation (BMT) model....

Recently, we developed an optimal decellularization protocol to generate 3D porcine myocardial scaffolds, which preserve the natural extracellular matrix structure, mechanical anisotropy, and vasculature templates and also show good cell recellularization and differentiation potential. In this study, a multistimulation bioreactor was built to provide coordinated mechanical and electrical stimul...

Colchicine, a potent neurotoxin derived from plants, has been recently introduced as a degenerative toxin of small pyramidal cells in the cortical area 1 of the hippocampus (CA1). In this study, the effect of the alkaloid in CA1 on the behaviors in the conditioning task was measured. Injections of colchicine (1,5 μg/rat, intra-CA1) was performed in the male Wistar rats, while the animals were s...

BACKGROUND Ischaemic conditioning, using short repeated sequences of intermittent ischaemia, is a strategy that may ameliorate ischaemia-reperfusion injury. The aim of the study was to assess the effects of direct and remote ischaemic conditioning in a porcine model of renal warm ischaemia-reperfusion injury. METHODS Pigs (50 kg) underwent laparotomy and 60-min occlusion of the left renal ped...

introduction: one of the hallmark symptoms of posttraumatic stress disorder (ptsd) is the impaired extinction of traumatic memory. single prolonged stress (sps) has been suggested as an animal model of ptsd, since sps rats exhibited the impaired fear extinction. oxytocin (oxt) has been recently suggested as a potential pharmacotherapy for treatment of ptsd. in this study, using sps rats we inve...

introduction: biological effects of magnetic fields have been investigated by scientists for many years and a vast amount of research using different frequencies and intensities have been performed on humans and laboratory animals. the results of these studies, which have mostly been done by applying high frequencies, have shown that electromagnetic fields are effective on structure and functio...