several factors including cancer, malformations and traumas may cause large facial mutilation. these functional and aesthetic deformities negatively affect the psychological perspectives and quality of life of the mutilated patient. conventional treatments are prone to fail aesthetically and functionally. the recent introduction of the composite tissue allotransplantation (cta), which uses tran...

background blood transfusion is one of the many ways, through which toxoplasma gondii (t. gondii), a protozoan parasite, can be transmitted to humans. objectives this cross sectional study aimed to evaluate the seroprevalence of toxoplasma infection and related epidemiological features among healthy blood donors. materials and methods a total of 375 blood samples from donors were tested for spe...

Abstract INTRODUCTION Tissue support is capital to achieve good results in reconstructive and aesthetic surgery. Radiotherapy, infection trauma among others are frequent predictors of surgery failure as they decrease tissue healing capacity. mobilization not always an eligible option raising comorbidities general population elder patients often seen daily practice. Furthermore, the possibility ...

Introduction. Developing a tissue-engineered pancreatic construct (TEPC) involves search for matrices/scaffolds capable of mimicking the structure and composition natural extracellular matrix (ECM), which is an important component tissue microenvironment. A cell-free, tissue-specific obtained from pancreas decellularization seems to be most suitable creation TEPC. The choice protocol should tak...

Abstract Myocardial infarction (MI) is a major disease posing significant threat to human health, as it leads necrosis of numerous cardiomyocytes (CMs), left ventricle dilation, and cardiac dysfunction, ultimately resulting in heart failure. Owing the shortage donors shortcomings current clinical treatment methods, resources have been dedicated developing platforms for tissue engineering, inclu...

In Chagas disease, CD8(+) T-cells are critical for the control of Trypanosoma cruzi during acute infection. Conversely, CD8(+) T-cell accumulation in the myocardium during chronic infection may cause tissue injury leading to chronic chagasic cardiomyopathy (CCC). Here we explored the role of CD8(+) T-cells in T. cruzi-elicited heart injury in C57BL/6 mice infected with the Colombian strain. Car...

PURPOSE Glaucomatous optic neuropathy is characterized by remodeling of the extracellular matrix with disorganization of elastic fibers in the optic nerve head (ONH). There are significant differences in prevalence of glaucomatous optic neuropathy between African Americans (AAs) and Caucasian Americans (CAs). The goal of this study was to evaluate differences in elastin synthesis and maturation...

BACKGROUND Mesenchymal Stem Cells (MSCs) are a promising therapeutic tool in veterinary medicine. Currently the subcutaneous adipose tissue is the leading source of MSCs in dogs. MSCs derived from distinct fat depots have shown dissimilarities in their accessibility and therapeutic potential. The aims of our work were to determine the suitability of omental adipose tissue as a source of MSCs, a...

Background: Human cytomegalovirus (HCMV) has been detected in tissue samples from patients with glioblastoma but little is known about the systemic immunological response to HCMV these patients. Objectives: To investigate presence and clinical significance of antibodies levels plasma obtained brain tumors. Materials Methods: HCMV-specific IgG IgM antibody were determined 59 collected tumor incl...