Non-malignant breast epithelial cells cultured in three-dimensional laminin-rich extracellular matrix (lrECM) form well organized, growth-arrested acini, whereas malignant cells form continuously growing disorganized structures. While the mechanical properties of the microenvironment have been shown to contribute to formation of tissue-specific architecture, how transient external force influen...

Due to the increasing number of heart valve diseases, there is an urgent clinical need for off-the-shelf tissue engineered heart valves. While significant progress has been made toward improving the design and performance of both mechanical and tissue engineered heart valves (TEHVs), a human implantable, functional, and viable TEHV has remained elusive. In animal studies so far, the implanted T...

Changes in the mechanical properties of soft tissues may be indicative of disease processes. Medical elastography techniques are an attempt to create images of the mechanical behavior to increase the sensitivity and specificity of existing imaging modalities. Current quantitative elasticity imaging methods rely on a priori assumptions of the tissue biomechanics in order to simply the forward pr...

To design more effective tissue-engineered heart valve replacements, the replacement tissue may need to mimic the biaxial stress-strain behavior of native heart valve tissue. This study characterized the planar biaxial properties of tissue-engineered valve leaflets and native aortic valve leaflets. Fibrin-based valve equivalent (VE) and porcine aortic valve (PAV) leaflets were subjected to incr...

Tissue Engineering In article number 2207882, Ryan Y. Nguyen, Michael Mak, and co-workers report the fabrication of collagen I hydrogels with topology that mimics complex extracellular matrix architectures in tissues. The generated mesoscopic features, termed islands, are tunable modulate bulk hydrogel mechanical properties. Collagen islands can stem cell behavior differentiation. This method p...

The load-strain and stress-relaxation behavior of wet rat tail tendon has been examined with respect to the parameters strain, rate of straining, and temperature. It is found that this mechanical behavior is reproducible after resting the tendon for a few minutes after each extension so long as the strain does not exceed about 4 per cent. If this strain is exceeded, the tendon becomes progressi...

in this study, thermoplastic polyolefin elastomeric (tpo) nanocomposites were fabricated by friction stir processing. the effect of different pin geometries on clay dispersion and mechanical properties of the tpo nanocomposite reinforced with 3% wt nanoclay has been first investigated. the optimum pin geometry namely threaded cylindrical pin was then used to fabricate the nanocomposites contain...

Mechanical forces are known to play a role in cell behavior and adaptation within their environment. In recent years, special attention has been paid to how these forces interact with various stem cell sources to direct stem cell differentiation. Embryonic, induced pluripotent, and adult or progenitor stem cells have all used in research involving mechanical stimulation. These various cell type...

Deformation behavior of a human dentin under compression including size and rate effects is studied. No difference between mechanical properties of crown and root dentin is found. It is mechanically isotropic high elastic and strong hard tissue, which demonstrates considerable plasticity and ability to suppress a crack growth. Mechanical properties of dentin depend on a shape of samples and a d...