The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine. Untargeted recombinant proteins, like activated protein C (APC) and thrombomodulin (TM), have demonstrated beneficial effects in acute vascular disorders, but have failed to have a major impact on clinical c...

Reduction in host activated protein C levels and resultant microvascular thrombosis highlight the important functional role of protein C anticoagulant system in the pathogenesis of sepsis and septic shock. Thrombomodulin (TM) is a critical factor to activate protein C in mediating the anticoagulation and anti-inflammation effects. However, TM protein content is decreased in inflammation and sep...

Reduction in host-activated protein C levels and resultant microvascular thrombosis highlight the important functional role of protein C anticoagulant system in the pathogenesis of sepsis and septic shock. Thrombomodulin (TM) is a critical factor to activate protein C in mediating the anticoagulation and anti-inflammation effects. However, TM protein content is decreased in inflammation and sep...

We introduce TM-NET, a novel deep generative model for synthesizing textured meshes in part-aware manner. Once trained, the network can generate from scratch or predict textures given 3D mesh, without image guidance. Plausible and diverse be generated same mesh part, while texture compatibility between parts shape is achieved via conditional generation. Specifically, our method produces maps in...

This paper presents a formalization for Topic Maps (TM). We first simplify TMRM, the current ISO standard proposal for a TM reference model and then characterize topic map instances. After defining a minimal merging operator for maps we propose a formal foundation for a TM query language. This path expression language allows us to navigate through given topic maps and to extract information. We...

Tetrathiomolybdate (TM), a drug developed for Wilson's disease, produces an anti-angiogenic and anti-inflammatory effect by reducing systemic copper levels. TM therapy has proved effective in inhibiting the growth of tumors in animal tumor models and in cancer patients. We have hypothesized that TM may be used for the therapy of rheumatoid arthritis and have examined the efficacy of TM on adjuv...

BACKGROUND/AIMS The trabecular meshwork (TM) tissue is constantly exposed to dynamic stress caused by intraocular pressure (IOP). The effects of such biomechanical stress on the TM have not been analyzed. This study developed an animal model of fluctuating IOP and evaluated the effects of these fluctuations on TM tissue. METHODS To create fluctuation in the IOP, one eye of adult SD rats was e...

Weak memory models trade programmability for performance, while transactional memory (TM) aims for ease of programming, sometimes at a performance cost. The semantics of both have been studied in detail, but their combined semantics is not well understood. This is problematic because TM is currently available, either natively or via extensions, in widely-used architectures and languages such as...

The equilibrium stress-strain relation and the pore radius of the isolated tectorial membrane (TM) of the mouse were determined. Polyethylene glycol (PEG), with molecular mass (MM) in the range 20-511 kDa, added to the TM bathing solution was used to exert an osmotic pressure. Strain on the TM induced by isosmotic PEG solutions of different molecular masses was approximately the same for MM > o...

OBJECTIVE This study aimed to determine how tympanic membrane (TM) perforations and their closure, using a paper-patch technique, affect middle-ear mechanics and, thus, conductive hearing for different sizes of the TM perforation. STUDY DESIGN Temporal bone (TB) study and prospective clinical trial. SETTING Tertiary referral center. PATIENTS Nine patients with chronic otitis media for mor...