the hyperimmunoglobulin e  syndrome is a rare complex primary immunodeficiency characterized by high serum ige levels, eczema, and recurrent infections. we present a case of 2-years-old girl with eczema and repeated bacterial skin and lung infections since the period of infancy. the patient also had eosinophilia, high serum levels of ige, and cows-milk hypersensitivity. we describe the case, in...

Speakers routinely provide cues in their utterances about their intended meaning that a listener must retrieve using inferential processes that go beyond pure lexical semantics and semantic composition. A classic example of this speaker-hearer meaning negotiation comes from conversational implicatures (Grice 1975). To take two well-known cases, if a speaker delivers the utterance in (1a) with t...

Little is known about toddler feeding practices, particularly among Mexican American mothers. A convenience sample of 18 Mexican-American mothers with toddlers participated in individual in-depth interviews. In determining what to feed her child, mothers tended to cater to the child's preferences rather than exposing the child to different foods or repeating attempts to feed previously unaccept...

We report a case of aspiration of calcium carbonate powder by a toddler. Bronchoscopic removal of aspirated contents resulted in favourable outcome.

A 13-valent pneumococcal conjugate vaccine (PCV13) has been developed to improve protection against pneumococcal disease beyond that possible with the licensed 7-valent vaccine (PCV7). This study compared the safety and immunogenicity of PCV13 with those of PCV7 when given as part of the pediatric vaccination schedule recommended in Italy. A total of 606 subjects were randomly assigned to recei...

BACKGROUND The objectives of this multicenter national study were to compare the clinical phenotype of early-onset inflammatory bowel disease (IBD) (EO-IBD) with IBD in older children and to examine whether there is any variability in consanguinity rate and familial aggregation in EO-IBD compared with later onset IBD. METHODS A retrospective analysis was performed on children aged 0 to 14 yea...