It has been proposed that pain competes with other attention-demanding stimuli for cognitive resources, and many chronic pain patients display significant attention and mental flexibility deficits. These alterations may result from disruptions in the functioning of the default mode network (DMN) which plays a critical role in attention, memory, prospection and self-processing, and recent invest...

Serotonin (5-HT) contributes to the prenatal development of the central nervous system, acting as a morphogen in the young embryo and later as a neurotransmitter. This biologically active agent influences both morphological and biochemical differentiation of raphe neurons, which give rise to the descending serotonergic paths that regulate the processing of acutely evoked nociceptive inputs. The...

Nicotinic agonists display a wide-range profile of antinociceptive activity in acute, tonic, and chronic pain models. However, their effectiveness is limited by their unacceptable side effects. We investigated the antinociceptive effects of two new α4β2* nicotinic partial agonists, varenicline and sazetidine-A, in acute thermal and tonic pain mouse models. Both drugs failed to induce significan...

Costus species is a significant restorative and decorative plant used to fix various illnesses. In India 6,000 plants are for traditional herbal medicine. The spicatus commonly known as ‘Spiral ginger’ ‘insulin plant’, wonder drug down blood sugar level hypoglycemic properties. has been found have numerous pharmacological exercises, example, antibacterial, antifungal, anticholineesterase, cance...

BACKGROUND We have proposed that nerve injury-specific loss of spinal tonic cholinergic inhibition may play a role in the analgesic effects of nicotinic acetylcholine receptor (nAChR) agonists on neuropathic pain. However, the tonic cholinergic inhibition of pain remains to be well characterized. RESULTS Here, we show that choline acetyltransferase (ChAT) signals were localized not only in ou...

BACKGROUND Musculoskeletal injuries stemming from forceful muscular contractions during seizures have been documented in the literature. Reports of multiple seizure-induced spinal fractures, in the absence of external trauma and without risk factors for fracture, are rare. CASE PRESENTATION A 28-year-old male, newly diagnosed with epilepsy, presented to a chiropractic clinic with the complain...

Copyright © 2010 by the Congress of Neurological Surgeons The management of chronic, intractable neuropathic pain by electrical spinal cord stimulation (SCS) is a well-established clinical method.1 The method is based on the gate-control theory of Melzack and Wall,2 who postulated that activity in large-diameter cutaneous fibers (Aβ fibers) inhibits the transmission of noxious information to th...

GENERAL SECTION Original Research Articles 628 Keren Reiner, PhD, Michal Granot, PhD, Eliran Soffer, MA, and Joshua Dan Lipsitz, PhD A Brief Mindfulness Meditation Training Increases Pain Threshold and Accelerates Modulation of Response to Tonic Pain in an Experimental Study The study examines effects of brief mindfulness meditation (MM) practice on pattern of change in response to tonic painfu...

OBJECTIVE Mixed evidence exists regarding whether irritable bowel syndrome (IBS) patients show increased somatic pain perception compared with controls. The current study used a deep, tonic somatic pain stimulus (ischemic pain) to evaluate somatic hypersensitivity in IBS patients. METHODS A total of 27 diarrhea-predominant and 15 constipation-predominant IBS patients, and 29 controls particip...

The present study examines the possible effect of the glucosylxanthone mangiferin (MG) on pain-related behaviors in a tonic acute pain model (formalin test at 5%) and in a chronic constriction injury (CCI) model to clarify the underlying transient and long-term mechanisms. Acute administration of MG (10-100mg/kg, i.p.) reduced licking/biting exclusivity in the tonic phase of formalin test in a ...