BACKGROUND The perioperative use of antithrombotic therapy is associated with increased bleeding risk after cardiac implantable electronic device (CIED) implantation. Topical application of tranexamic acid (TXA) is effective in reducing bleeding complications after various surgical operations. However, there is no information regarding local TXA application during CIED procedures. The purpose o...

Methylsalicylate-containing rubefacients have been reported to cause salicylate poisoning after ingestion, topical application to abnormal skin, and inappropriate topical application to normal skin. Many over-the-counter products contain methylsalicylate. Topical salicylates rarely produce systemic toxicity when used appropriately; however, methylsaliclyate can be absorbed through intact skin. ...

The activity of dietary and topical administration of three retinoids, all-trans-retinoic acid, 13-cis-retinoic acid, and N-(4-hydroxyphenyl)retinamide (4-HPR), as promoters of skin tumor induction in SENCAR mice was studied. When administered as dietary supplements at their maximum tolerated dose levels, all three retinoids promoted tumorigenesis in mice initiated with a single topical dose of...

Objective. To test the hypothesis that the application of 4% cocaine-soaked cotton pledgets to each piriform sinus for one minute represents a safe and efficacious method of providing additional topical anesthesia for fiberoptic bronchoscopy. Materials and Methods. We retrospectively reviewed all FBs performed at Mayo Clinic Jacksonville from January 1999 to April 2004. Data abstracted included...

Immune mediated inflammatory anterior segment diseases are variable and their management requires intense immunosuppression. Treatment with topical steroids is associated with serious ocular side effects. In order to overcome the potentially blinding complications of topical steroids, immunomodulatory drugs are being used more frequently. Tacrolimus is a calcineurin inhibitor that induces suppr...

Effects of chlorogenic acid on surfactant-induced itching were studied in mice. Topical application of sodium laurate increased hind-paw scratching, an itch-related response, 2 h after application, which was inhibited by topical post-treatment with chlorogenic acid. Sodium laurate increased the histamine content and 53-kDa L-histidine decarboxylase in the epidermis, which were also inhibited by...

A case is presented in which respiratory distress resulted from the production of methemoglobin Following application of topical benzocaine to a child’s oral mucous membrane. Modern local anesthetics are among the safest of administered agents, with few reported cases of morbidity or mortality. The use of topically applied local anesthetic agents is important in the atraumatic administration of...

OBJECTIVE Comparing the effect of topical human milk application and dry cord care on cord separation time. METHODS This research was a randomized clinical trial study on 130 singleton and mature newborns. Newborns were placed randomly in groups of topical application of human milk and dry cord care. The umbilical separation time was compared in the two groups. Data was analyzed by SPSS softw...

J. Econ.Entomol.78: 722-724 (1985) ABSTRACT A residue on glassexposure technique was compared with topical application as a method of assessingpermethrin resistance in a house fly (Musca domestica L.) population. Multiple levels of treatment permitted development of significant dosage-mortality lines with both techniques. Average resistance factors were ca. 150 with the topical application tech...

A small body of literature has been published reporting the application of topical oxygen for chronic non-healing wounds . Frequently, and erroneously, this form of oxygen administration has been referred to as "topical hyperbaric oxygen therapy" or even more erroneously "hyperbaric oxygen therapy." The advocates of topical oxygen claim several advantages over systemic hyperbaric oxygen includi...