Few health care professionals realize that topical anesthetic spray can cause methemoglobinemia. We describe a 56-year-old woman who was transferred to our emergency department when severe cyanosis and chest pain developed after administration of topical oropharyngeal benzocaine and lidocaine during outpatient endoscopy. Investigations revealed a methemoglobin level of 51%. Despite rapid diagno...

Levocabastine is a new H(1)-receptor antagonist specifically developed for the topical treatment of seasonal allergic rhinoconjunctivitis. Clinical experience to date clearly demonstrates that levocabastine eye drops and nasal spray are effective and well tolerated for the treatment of this allergic disorder. Analysis of data from a number of comparative trials reveals that topical levocabastin...

BACKGROUND The topical administration of eyedrops is often an unpleasant procedure in the pediatric population. We sought to learn whether a combination mydriatic-cycloplegic solution would be an effective cycloplegic if delivered as a spray. METHODS We conducted a prospective, examiner-masked, parallel-group study and randomized 38 subjects (age range 6 months to 12 years, mean = 7.3 years) ...

BACKGROUND Controversy still exists about the treatment of rhinitis medicamentosa and treatment has never been objectively evaluated. OBJECTIVE To study the effect of fluticasone propionate aqueous nasal spray compared to placebo nasal spray in the treatment of rhinitis medicamentosa. METHODS A parallel randomized, double-blind study was conducted to evaluate the treatment of rhinitis medic...

OBJECTIVES This study aims to evaluate the efficacy of mometasone furoate nasal spray, intranasal azelastine, and isotonic sea water nasal spray in the management of allergy-induced nasal obstruction. PATIENTS AND METHODS Between October 2007 and August 2008 60 patients (37 males, 23 females; mean age 9.8±2.6 years; range 7 to 16 years) with a history of allergic rhinitis were included in the...

BACKGROUND Increasing antibiotic resistance of Propionibacterium acnes and growing awareness on the side effects of topical and systemic drugs in the treatment of acne vulgaris by physicians and patients have paved the way for a search into new efficacious and safe treatment modalities such as photodynamic therapy (PDT). Although the efficacy of PDT using 20% 5-aminolevulinic acid (ALA) cream h...

Correspondence To the Editor: In a single‑center, prospective, randomized double‑blind clinical study comparing dexmedetomidine‑ midazolam and sufentanil‑midazolam sedation regimens for awake fiberoptic intubation (AFOI) in 50 patients with difficult airways due to limited mouth opening, Li et al. show that both dexmedetomidine and sufentanil are effective as an adjuvant for AFOI under airway t...

Topical steroids are widely used in the treatment of allergic rhinitis and have recently become available as an over-the-counter product (Beconase nasal spray). They are considered safe since it is believed that they are not absorbed in large enough quantities to have systemic effects. Reports of adverse effects relating to their use are rare.' We report a case of iatrogenic Cushing's syndrome ...